Marketing. Performance evaluation Essay Example | Topics and Well Written Essays - 750 words

Marketing. Performance evaluation - Essay Example It would not be correct, if we only hold the employee responsible or if we hold solely the employee responsible for this immorality. An employee involves himself in such act because there is not adequate check on him, which is the responsibility of the company. However, the primary fault is that of the person himself. It is the immorality of the individual that actually works on promoting such unethical practices at company time. Hence, the person responsible for the act is to be held responsible; however, the boost to these activities given by company environment is also to be considered. Discussion Question 2: Please discuss your views of performance expectations or performance appraisals and how they accurately or not evaluate your performance Do you feel the annual evaluation you have each year accurately reflects your performance on the job What are some ethical implications related to performance evaluations Performance evaluation is said to be a yardstick for measurement and decision of whether an employee has performed according to expectations or not and if yes, how good has been the performance. Performance evaluation techniques have a structured approach followed by discussion to have a conclusion of the employee's performance. An employee is allowed to present his case through self evaluation but the final judgment is that of the boss. The annual frequency of this tool is for ease and convenience. However, there are times when the employee has been a great performer throughout the year, and just when the evaluation time is near, due to some reason the performance has slipped. In such cases, performance evaluation results do not go in the favor of employee in spite of quality and hard work all the year round. This makes performance evaluation a subjective tool to a great extent. So, better frequency can remove this drawback rather than having an annual appraisal. Ethically, it is the employee's responsibility to do a realistic and correct self appraisal and even the boss is morally bound to give the deserved rating. But, in actual scenario, the case does not match ideal needs. The employee does try to inflate and show his performance and aims at maximum rating in spite of whatever the performance is. Exceptions are always there. Also, the boss tries to have personal bias while evaluating. Hence, the ethical sense of the tool gets lost. Summary: The course on critical thinking and ethics offers a pathway to integrate the views on ethics in the professional as well as personal life. It has an impact on the thought process and helps getting a realistic view of things around us and facilitates evaluation of professional and personal development in the light of ethical standings. It also enables to let us apply theoretical topics and discussions for decision making and for assessment of skill sets and talent. The above two discussion questions give a food for thought for the immorality and morality debate at work place. It helps in analysis of the actual scenario versus the expected scenario. The collaborative effort of the course with a structured approach and discussion based topics of real life stimulate the

Decision Making, Decision Levels and Types of Problems Essay

Decision Making, Decision Levels and Types of Problems - Essay Example This root of the system is primordial and through interactions with each other and combinations becomes more advanced and complex assembling progressively more complex level of systems that cooperate and exchange information and ultimately forming an information system. Information systems theory postulates a system as a symbol within a representational medium (idiom) and the representational medium in itself. The general systems theory can be applied in structured problems to solve information system problems, where the problem and desired solution is clearly defined and can be split into a series of steps that are well defined (Skyttner 2001). For example, in developing an information system for an online retailer, a structured approach would be to list the products being sold, the available staff and the processes that will lead to making a sale, in which case a product inventory can be made. Members of staff are then allocated duties such as customer service and dispatch then how data on available inventory and deliveries will be made. In this case, what is needed is clearly defined. The inventory, who will handle what and how items will be delivered to customers so a system development sequence is employed. The general systems theory can be applied in structured problems to solve information system problems, where the problem and desired solution is clearly defined and can be split into a series of steps that are well defined (Skyttner 2001). For example, in developing an information system for an online retailer.... A decision support system (DSS) then comes in handy, as there is a need for some level of intuition. The DSS will do most of the ‘thinking’ as it provides data and models to help management make decisions. Non-structured situations would be for example designing a web site that can process payments from customers online, receive orders and queries and interact with a customer. Intuition will be needed on what would be most suitable for the customer and how to reduce threats of credit card fraud to the customer. The exact situation is not fully known but forms the wider system requirement and hence the solutions are not straight forward (Mathews 2008) General systems thinking is the practice of appreciating how different parts of an information system can impact and influence each other. For example, in designing a database system for a supermarket, one has to know how the accounting system will interact with the stock and inventory system and the payroll. In terms of str uctured problems, a designer can look at how the check out system will update the daily sales records and the stocks. The problem is defined as updating the daily sales account and knowing how much of what was sold. The problem can be designed in defined steps from what system to capture what has been sold, and for how much and then the stocks must be updated. A semi-structured problem would be how to know when stocks are running low or when to take money to the bank. A threshhold for cash sales will have to be established that alerts the finance manager to call in the couriers to deliver money to the bank. The system to know how much sales came from what products and how many were paid for by credit card. A non-structured problem would be how to handle customer complaints, track their

Attachment Theory Young Children And Their Families Social Work Essay

Attachment Theory Young Children And Their Families Social Work Essay Attachment theory derives from psychoanalyic psychology, however it is used in social work to attempt to understand behaviour in infancy and childhood to show the way in which children develop emotionally (WALKER 2009) This theory centres on the idea that children need to form secure relationships with other people, such as parents or guardians, as it is a significant contributer to their emotional development. Social bonds and relationships that are made in early childhood are believed to influence an individuals life and can impact upon their well-being to determine their emotional and social stability later in life. Consequently, attachment is seen as an integral component within infants and young childrens lives, as these experiences can shape a persons personality and identity in future years. (WALKER, J and K, CRAWFORD 2010). If these experiences of attachment are negative, and the child does not develop adequate relationships with their caregivers, then this can have detremental consequences on their psychological and emotional development. (WALKER, J 2009). The Attachment theory originates from the ideas of John Bowlby who believes that humans are biological predispositioned to seek attachment from others. He proposes that survival is closely related to the ability to possess emotional bonds with other individuals (GREEN 2003). This is because by forming an attachment with an authority figure who is seen as the stronger of the species, this reduces the vulnerability of the individual as it provides increased security and protection from harm posed by potential predators (BOWLBY 1958, cited in LISHMAN 2007). The theory looks at the way that attachment relationships are formed, and the reasons behind their manifestation. Children are seen to form these relationships for reasons such as safety, comfort and to provide guidence. These attachment behaviours, according to learning theorists, are displayed in infancy through talking, laughing and crying. This enables them to persue their basic needs for survival, such as food for nurishment, by their attachment to their mother who is able to support them in fulfilling their needs (WALKER, J and K, CRAWFORD 2010). This initial attachment to caregivers also guides the individuals thoughts, feelings and expectations as they become aware of peoples responses towards them which help them recognise how to behave (WALKER 2009). There are four assumptions of Bowlbys attachment theory which attempt to explain his beliefs. The first, is that infants and young children develop emotional ties with individuals early in life, which acts as a biological function and plays an integral part to their survival. The second assumption is that the way a child is treated early in life has a major contributing factor to their future relationships and the way their personality is formed. The third assumption is that attachment behaviour can form an internal working model which guide the childs thoughts, feelings and expectations as a result of the reactions of others towards their behaviour. The final assumption of Bowlbys attachment theory is that although it is difficult to alter attachment behaviour, it is not impossible, thereofre there is the possibility of alteration at any point in life, both in a positive and negative way (GREEN 2003). Although infants and young children are able to have more than one attachment figure, they are still affected when they are exposed to seperation from their primary attachment figure. This can happen for many reasons, such as a child being removed from a family home and placed into care, or perhaps death. This can be a very distressing and confusing time for a child as they are unsure of who to turn to for security and protection. This is evident in social work practice in instances where an abused child wants to remain with its parents, even though it is not a stable or supportive attachment (LISHMAN 2006). Bowlby proposed that children who have experienced seperation from their main attachment figure will suffer in a process involving protest, dispair and detachment, in an attempt to overcome their loss (BOWLBY 1958, cited in LISHMAN 2006). However, although Bowlby provided an important contribution to the idea of attachment, his research can be criticised in many ways. This is because Bowlby tends to focus his ideas on one primary figure of attachment, often the mother, when it is possible for children to form attachments with other people within their lives such as their father. Also, developing relationships with other people alongside the attachment figure is also important, this is because having to rely on the caregiving relationship of one person can be detrimental due to the fact it often results in dependency and does not allow other relationships to be formed with others, which can the hinder the social and emotional development of the child (WALKER, J and K, CRAWFORD 2010). According to Lishman (2007), the attachment theory believes that when a child is stressed or afraid, they exhibit particular behaviour and emotions which can be perceived as attachment. This is because they seek protection from harm through the help and security of an adult who they see as stronger than themselves. This is closly linked to two types of behavioural systems: the exploratory behavioural system and the fear behavioural system. The exploratory behavioural system is based of the belief that when an infant or young child feels comfortable and safe, the attachment behaviour remains dormant and therefore the child will be willing to explore the people around them and their surroundings. However, if a child feels threatened or vulnerable, the fear behavioural system will become active, where the child will no longer seek exploration and instead they will seek protection from their attachment figure and exhibit behaviour related to that attachment. However, the behaviour that they display is not intended to provoke affection from the attachment figure, instead it is to à ¢Ã¢â€š ¬Ã…“regain a state of equilibriumà ¢Ã¢â€š ¬Ã‚  (p59). This means that infants and young children are not dependent upon the caregiving nature of the attachment figure, instead their aim is to diminish their fears. There is a classification of attachment patterns which identifies four different types of attachment, which attempts to enanble professionals to assess young childrens behaviour and emotions (secure, ambivalent, avoident and disorganised). Secure attachment is based of the belief that children depend upon their caregiver as a base for exploration. The caregiver is available to the child and responds to the childs needs, therefore the child behaves in a positive manner. Ambivalent attachment looks at how children are unwilling to explore their surroundings as the caregiver is not consistent in their support. This can leave the child distressed, clingy and dependent. The third category is avoident patterns of attachment, and features an unresponsive caregiver, therefore the child feels rejected and they view themelves as dependent whilst actively avoiding or ignoring the caregivers presence. And finally, disorganised attachment is where children are fearful of their caregivers, and the y themselves may feel confused or depressed. This type of attachment is most often seen in children who have suffered abuse (HOWE 2001, cited in LISHMAN 2007). How a critical understanding of Attachment Theory can contribute to Social Work Practice. Social workers are seen to have three roles to play when working within an attachment perspective: assessment, planning and direct work with children, parents and carers. Assessment looks at areas within attachment such as the needs of a child, the parenting that they receive, their emotional and behavioural development and the relationships which they have formed. There are also tests created specifically for measuring attachment, such as Ainsworths stranger test which provide an indication of the pattern and quality of their attachments. The second role, planning, looks at how planning for new attachments when placing children with new families needs to be approached carefully. This is because they need finding the most suitable parenting figures where new attachments can be made. The third role is direct work with children, parents and carers. This is because direct contact and communication is necessary to achieve the best possible outcome when working with children and families. For example, when a child has been removed from their home and is being placed with new carers, direct work can provide support to the child to prepare them for change. It can also be useful with the adoptive or foster family to provide guidence and support towards what to expect and to help with any problems they face (LISHMAN 2007) Attachment theory has been used within social work practice as the basis for many child care policies. This is because the idea of a infant or child being attached to their family, which can influence their development in many ways, has been used as the basis for many legislation (LISHMAN 2007). For example, Sure Start Childrens Centres have been introduced in response to the importancy of family support to enable them to build and maintain positive family relationships (LAMING REPORT 2009, cited in BRAMMER 2010). Attachment theory had also contributed to policies such as shared parental responsibility, as it has emhasised the need for emotional and social relationships with caregivers, whilst also suggesting possible consequences to a childs development and the negative impact later in life if these needs were not met effectively. (LISHMAN 2007). Attachment theory also provides guidence to enable social workers to judge the quality of a relationship between a child and its parents. This can enable them to gain an understanding of at what point, if at any, intervention is necessary as it gives them the ability to evaluate the attachment that is present within the relationship. The attachment theory also gives a more comprehensive understanding of the loss experienced by an infant or child when they lose their main attachment figure. This means that people working within social work practice are aware of the common and typical behaviours of a child who is going through this process and can therefore support them to overcome it. A further way the attachment theory is used to benefit social work practice is that as it is known that attachment figures are necessary for children to develop adequately, individuals such as adoptive parents can be taught to exhibit behaviour which will encourage new attachmentment from the child which is needed for personal growth (WALKER, J and K, CRAWFORD 2010). However , care needs to be taken when placing a child with a new family as to prevent a repeating loss of attachment figures which can cause them to blame themeselves and produce feelings of worthlessness. This can mean ensuring that the child is appropriatly prepared and ready to form new bonds of attachment and that the new carers of the child receive sufficient support within their role. (LISHMAN 2007). Attachment theory can also be linked to the way in which a mother bonds with her new born baby. However, these early bonds are not solely restricted to mothers, it is also possible for fathers. Although, this bond is typically formed within the first few hours after birth as the mother and baby connect both physically and emotionally. The initial bond that is made is thought to have a significant effect on their future relationship as it is the beginning of their attachment. This knowledge enables social workers to support mothers who are particularly vulnerable to poor parenting, although this is only effective if the support continues throughout the first few months after the baby is born.. However, it is important to note that just because a mother fails to achieve an initial bond with her baby, this does not mean that abuse is inevitable. How are issues of diversity relevant to human growth, behaviour and development? GREEN, V. 2003. Emotional development in Psychoanalysis, Attachment Theory and Neuroscience: Creating Connections. East Sussex: Brunner-Routledge LISHMAN, J. 2007. Handbook for Practice and Learning in Social Work and Social Care: Knowledge and Theory. London: Jessica Kingsley WALKER, J and K, CRAWFORD. 2010. Social Work and Human Development. Exeter: Learning Matters WALKER, J. 2008. Studying for Your Social Work Degree. Exeter: Learning Matters BRAMMER, 2010. Social Work Law. London: Longman

Love and War Essay -- Literary Analysis, The English Patient

War has the capacity to foster love while equalizing social status. The novels The English Patient by Michael Ondaatje and A Town Like Alice by Nevil Shute substantiate the fact, through fiction, that during war-time men and women who are not of the same station in life can find an incomparable love with one another. Each novel also gives evidence of love igniting during war and surviving the trials of time and distance. Hana and Kip from The English Patient and Jean and Joe both go through these trials and tribulations associated with love and war. Whether that love is doomed for failure or a future together forever†¦it never dies. The love between men and women of different stations during times of war is manifested in The English Patient between Kip and Hana. Kip and Hana have a cultural difference due to race. Their identities are diverse from one another. Kip was born in the Punjab and raised in India while Hana is a white young woman from Canada and that difference in any other environment would have had an impact on the closeness of their relationship. A relationship between the two in a normal environment would have been unusual. Although Kip’s cultural heritage and skin color is different from Hana, Kip see’s himself as more English than Indian after he spends so much time identifying with other Englishmen. Kip finds himself in a very perplexing situation. He begins transforming and accepting English traditions into his life, while still trying to hold on to his own Indian traditions. Racial tensions were high during the 1940’s, and Indians in England were seen as second class cit izens. â€Å"In England he was ignored in the various barracks, and he came to prefer that† (196). Kip’s self-sufficiency, â€Å"†¦was as much a result ... ...ove and devotion to one another. â€Å"‘Dear Joe. Of course I’m in love with you. What do you think I came to Australia for?’† (248). They had found a bond in the war based on need, a need for companionship and understanding, and in that need they later discovered an enduring love that could never die. During times of war love is cultivated and social statuses are eradicated. War wipes away all the concerns with petty things in life while lifting up the values that we hold so strongly to within our hearts and souls. War makes people remember what is truly important in life and gives individuals a sense of purpose. Love and friendship are unbreakable bonds that we as humans cherish. All of the trivial concerns in our civilized world often tend to make us temporarily forget that fact. Love makes us human, especially during times of war when people can seem so inhumane.

Cheating in College Exams Essay

Although there are a lot of just and honest students in colleges right now others don’t care about their education. Students continually try to cheat their way trough graduation. But the dilemma comes when they find out that the consequences are more significant that the grade they received. Nowadays there are a lot of uninvolved parents, most of them don’t sit with their child to help them with their homework or talk to them about the importance of school from an early age. All they care about is bringing money and food to the household; because of this children are being raised without morals and since this is the fist education they receive and is one that will impact them for the rest of their life, kids don’t learn that a letter is just a letter and that the important aspect of school is what you get out of the discussions, homework, and exams. The media doesn’t help in any way, constantly coming out with movies like â€Å"Slackers† or â€Å"The Perfect Score† where a group of teenagers decide to break into the Princeton Testing Center, so they can steal the answers to their upcoming SAT tests and all get perfect scores. The main focus of these kinds of movies are people ranging from 9 to 20 years of age and most of these films are rated pg13 so many kids can go in by themselves and get these images of how cool it is to cheat and how easy it is to get away with it. So having this view present in their heads they grow with a sense that there is nothing wrong with cheating as long as you are a reasonably a good person , and a law-abiding good standing citizen. Event ought teachers have in no way fault in the reason why students cheat on their exams professors could make it a little more difficult for students to do it, or at least get more creative with the way they provide exams. Some students here at BCC, including myself have at some pint or another been approach by another student that is going to take the class we’re in right  now, and we have been asked for a copy of the exams or the scantron sheets so that they can cheat and get a good grade the next semester that they enroll in the class we’re in right now. Because a lot of instructors don’t give essay exams, or another type of exams students can easily get a hold of tests from students that were on the class in previews semesters. This problem although rarely occurring, does happen, and if not addressed it will allow student to keep on cheating their way though college. The problem of cheating can be analyzed from a lot of points of view, and there are a lot of solutions that if implemented from early childhood, reinforced while receiving a negative image of this actions (unmoral, and not cool), and also including a little help from the teachers can result in students realizing and finally deciding not to do this because it is wrong to do it and because it is really hard to do it. If students understand that what they don’t learn right now may some day come up in their careers and make them look like a fool, they would not do it and they would not blame anybody for their actions because when cheating the only culpable is yourself.

Traditional Sports in Assam

Traditional sports in N-E Games soon| A STAFF REPORTER| | A traditional sport in progress during the recent Bihu festivities. A Telegraph picture | Guwahati, May 22: The newly-formed Assam Traditional Sports and Dragon Boat Association claimed that efforts were being made to include some traditional sports of Assam in the North-East Games in near future.Addressing the media, regarding the proposed traditional sports carnival — Amar Khel, Amar Utsav — on Saturday, one of the founder office- bearers of the association, Subhash Basumatary, said he was making efforts to get a few disciplines included in the North-East Games, organised annually by SAI. Basumatary is also the director-in-charge of the SAI regional sub-centre, Guwahati. Boat racing, one of the most popular traditional sports, is all set to be the first from among a dozen traditional deciplines which could make it to the North-East Games.The Dragon Boat carnival, to be held here on Saturday, will include 10 oth er disciplines apart from boat racing at Dighalipukhuri. The field events at the carnival at Latasil ground include dhop khel, koni juj, ghila khel, malla juddha, rashi tana, tel khuta, tangon tona, kelah loi dour, tekeli bhonga and dighal thengia dour. â€Å"The idea is to conserve the traditional sports and bring them out of the remote villages to the urban areas. We hope to get co-operation from the government too in organising the event.So far, the tourism department, the State Sports Council of Assam, the Kamrup (Metro) district administration and few others have already come forward to help us in the noble venture,† the association’s president Taher Ahmed said. | Dhopkhel The most popular indigenous game in the state of Assam is Dhopkhel. An ancient game, it is closely related with the development of the state as such. The game requires absolute physical fitness – speed, stamina and acrobatic skills. Dhop is a seasonal game, played during the state's Sprin g Festival, known as Rangoli Bihu.The game really flowered under the royal patronage of the Ahoms. There are two types of Dhop, one played by men and the other by women. The game, which uses a rubber ball, is played by two teams comprising 11 players each, in an open field, 125 m in length and 80 m in breadth, with a central point in the right middle of the arena. Two lines called kai are drawn at a distance of 12 ft on each side of the point at the centre. At the four points where the kai meets the 125 m lines, four flags are planted. Similarly, four flags are planted in the four corners, known as chukor nishan.Parallel to the central point in each half of the field, is one point each, at a distance of 13'6†³ from the centre, and circles surrounding them known as gher. The game begins with the dhop i. e the ball being thrown in the air, by a player. If the ball does not fall in the opponent's court, it is to be thrown again. The dhop has to be caught by the opposing team, and if they fail, then the other team takes the throw. If caught, the player who takes the catch proceeds to the gher of the court, and throws it to the katoni, who stands on the other gher.If the thrower fails on either count, his team forfeits the chance of a throw at the katoni, and the guilty player is requested to deliver a high lob to the opposing team, like the lob which started the game. The opposing team thus gets a chance once more for a catch and throw, at the opponents' katoni. If the katoni is hit below the waist, it is considered a kota, and the katoni becomes a hoia or a bondha, and automatically loses his status of a ghai – a name initially used for all the players. The bondha goes over to the opposing side and tries to prevent the players of the team from catching the dhop. This move is known as aulia.If a bondha succeeds in catching the dhop in the opponents' court and can recross over to his original side without being touched by any of the opponents, he become s a ghai, and this move is known as hora. However, he has to cross both kais and he cannot leave the court in the process of crossing over, or catching the dhop in the zone between two kais. If a team loses ten ghais as hoia or bondha, then the last ghai will be named ghai katoni, and if a kota can be done to him, then it is known as piriutha, which signifies victory for the side. If at the end of the game, there are equal number of ghais, the game is pronounced a draw. Rang GharLocation: Joysagar, 4 km to the west of Sibsagar town Built By: Ahom King Pramutta Singha Built In: 1746 AD Highlights: Oldest amphitheatre in Asia Rang Ghar is one of the major attractions of the state of Assam. It is said to be the oldest amphitheatre in the whole of Asia and has often been referred to as the ‘Colosseum of the East'. Situated to the northeast of the Tolatol Ghar, in the Joysagar area of the Sibsagar district; is the two storied Rang Ghar, which was the royal venue for witnessing a nu mber of games, like buffalo fight, bull fight etc. This ancient amphitheatre was constructed by the Ahom ruler Swargadeo Pramutta Singha.Rang Ghar dates back to 1746 AD, when it was basically built for the purpose of amusement and fun. The theatre is a double storied building and on the roof, there is a design of an Ahom royal long boat. It is overall oval in shape, unlike the multi-storied Tolatol Ghar situated just adjacent to it. Every year, during the occasion of Rongali Bihu, Rang Ghar used to be the royal sports pavilion, from which the Ahom kings and nobles witnessed games in the Rupahi Pathar below. The Rupahi Pathar is a vast field, where various activities like bull fighting and other such traditional games used to be organized for the entertainment of the royalty.The Rang Ghar was even the symbol of the recently concluded 33rd National Games, which was held in February (9th to 18th) 2007, in Guwahati, Assam. In case you are planning to visit Sibsagar district of Assam in the near future, do make sure to pay a visit to the Rang Ghar as well. Rang Ghar (Assamese: , rong ghor) (meaning â€Å"Amusement House†) is a two-storied building, which was the royal sports-pavilion from which the Ahom kings and nobles witnessed games like buffalo fights and other sports at the Rupahi Pathar (pathar meaning field in Assamese) specially during Rangali Bihu festival in the Ahom capital, Rangpur.On the roof of the Rang Ghar is a design of an Ahom royal long boat. The building was constructed during the reign of Swargadeo Pramatta Singha in 1746. It is located north east to the Talatal Ghar a multi-storied royal complex in Joysagar west of Sivasagar town, on the other side of the Assam Trunk (AT) Road in Sibsagar district in Assam, India . The Rang Ghar is said to be the oldest amphitheater in Asia[citation needed]. The base of the monument has a series of arched entrances and atop the roof is a decorative pair of carved stone crocodiles.In many of these, only the brick framework exists with vestiges of sculptural adornments here and there. The Ahoms, who used special thin baked bricks, did not have the use of cement and, therefore, used a paste of rice and eggs as mortar for their construction. They also made use of powdered mixed lime and bricks to cover the surface of the inner walls. It is said that this layer of powder used to keep the inside of Ranghar cool. The entrance to Sankardev Kalakshetra at Guwahati is made in the style of the Rang Ghar.The Rang Ghar was the logo of the recently concluded 33rd National Games that was held from 9 to 18 February, 2007 in Guwahati, Assam. About a kilometer towards the north east of Rangh Ghar is the Jaysagar Pukhuri. It is a manmade tank, encompassing an area of about 120 Bighas of land. It was dug in memory of Rani Joymati, the mother of Rudra Singha, the most illustrious of the Ahom kings. Guwahati, Apr 6 (PTI) Seisimic survey work by the ONGC is posing a threat to Assam's 18th century amphi theatre, ‘Rang Ghar† at Gargaon in Sibsagar district, perhaps the largest stadium in Asia, which has proudly stood the ravages of time.Lesser known than the internationally famous `Colosseum' in Italy, the ‘Rang Ghar' bears mute testimony to the state's chequered history. The most potent symbol of the glorious 600 year rule of the Tai-Ahom kings hailing from Thailand, the monument constructed in 1746 AD, has been in the news after a report carried by PTI on cracks appearing on its facade. The report prompted the Assam government to constitute a seven-member expert committee to examine the damages on the walls of the heritage site.The damages to the protected monument have prompted the Archaelogical Survey of India (ASI) which maintains it, to threaten legal action against the public sector Oil and Natural Gas Commission (ONGC) The ASI move comes after eight 10 metre cracks have appeared on the Rang Ghar walls following blastings in the seismic survey work at nearby Rupohipathar, an open oil field. The ONGC officials when contacted refused to comment on the matter and only maintained â€Å"that precaution had been taken not to harm the heritage sites and historic monuments during survey works†.The damages have created a public outcry with a local students body, All Assam Tai Ahom Students Union (AATASU), calling an ‘indefinited ONGC bandh' from March 5 and the proscribed ULFA issuing a warning to the ONGC to stop all seismic work or face dire consequences. The Rang Ghar, stated to be the oldest outdoor stadium in Asia, bears mute testimony to Assam's history. The medieval Tai-Ahom kingdom (1228-1826) was founded by Sukapha in the 13th century establishing its suzerainity over the Brahmaputra valley and putting paid to Mughal expansionism in the North-East seventeen times sucessfully.The monument also saw the annexation of Assam by the British Empire through the historic Treaty of Yandaboo in 1826 paving the way for the advent of t he Britishers into the state and the end of the 600 year old Ahom rule. The monument at Gargaon was the crucible of the proscribed ULFA movement with its leaders congregating under Rang Ghar's portals on April 7 nearly 30 years ago to script one of the most violent chapters in the annals of the state in its fight for an independent homeland.The original ampitheatre was constructed with wood and bamboo by King Rudrasingha, also known as Siukapha who ruled between 1696-1714, but was rebuilt into a permanent structure by King Pramatasinha (1744-1751). With no knowledge of modern day cement, the Ahoms used a paste of rice and eggs as mortar and special thin bricks for construction of the Rang Ghar, that has withstood decades of neglect till Independence. As its name suggests, ‘Rang Ghar' was a `merriment house or a place of joy'. It was in this sports pavilion that elephant, buffalo, bullock and hawk fights, wrestling, besides Bihu (Assamese cultural festival), etc. were held. The Mongolian style oval-shaped two-storyed pavilion is 10 metres high, 11 metres across and 27 metres long with a steep flight of steps leading to the higher elevation from where the royal patrons and nobles are presumed to have watched the contests on the Rupohi Pathar (field) below surrounded by a huge meadow meant for the royal subjects. The monument's base has a series of archways with vestiges of sculptural adornments, and its roof is designed like a royal long boat with a pair of carved stone crocodiles on either ends.The ampitheatre is located north east to the royal palace `Kareng Ghar' in modern day Sibsagar town in Upper Assam. The Ahom kingdom with a successful multi-ethnic polity made major advances under king Susengpha Pratap Singha who revamped the administration and established the first military and diplomatic contact with the Mughals. Under King Gadadhar Singha, Mughal influence was, however, completely removed from the Brahmaputra valley and the Ahom Kingdom achieved its golden period under his son Rudra Singha.The Ahom rule declined with the rise of the Moamoria rebellion and subsequently fell to a succession of Burmese invasions. The defeat of the Burmese after the Anglo-Burmese War and the treaty of Yandaboo on Fewbruary 24, 1826, control of the once glorious Ahom kingdom passed into the British hands. Though during the colonial and subsequent times the Tai- Ahom rule was called the `Ahom Kingdom', the Ahoms called their kingdom `Mong Dun Shun Kham (casket of gold), while others called it Assam. The Rang Ghar was the logo of the 33rd National Games held in Guwahati from February 9 to 18 last year.

Apply the Rod or Spoil the Child essays

Apply the Rod or Spoil the Child essays It is the natural scheme of life. Human beings produce children and thus are classified as parents. It is and has always been the parent's job to raise and nurture the child, to teach it right from wrong, and to protect it from the harshness of the surrounding environment. However, when the child strays or behaves in a destructive manner, what steps should a parent take to correct such behavior? Some psychologists suggest that a good old-fashioned spanking is just the ticket. Others say that such action will emotionally damage the child later in life. With the parent ultimately responsible for the child, it's hard to know what is right or wrong when your 3 year-old is beating his head against the floor in a full-blown temper tantrum. 25 years ago, parents would have picked the child up, spanked it, and taken care of the tantrum effectively. Today, parents are more apt to try anything other that a swat on the behind. Reason, however, doesn't impress a 3 year-old so the behavio r is often ignored because passive parents don't want to risk mentally scaring their child. The experts have basically made a huge issue out of something very simple. If spanking is as harmful as they say it is, then every human being over the age of 30 is a mental case. Spanking is not the answer for everything, but in some cases it is the only answer. The growing trends for passive discipline in the United States stem largely from the revelation that there were people out there that severely abused their children. As more and more abuse cases were brought to light, laws were changed to protect the child.1 Psychological issues soon began to crop up and spanking soon came under fire, being called a form of child abuse and in some cases punishable under the law. Researchers have studied the effects of spanking and the effects are not to be taken lightly. First of all, the experts claim that spanking doesn't teach a child self-direction. The child le...

Free Essays on Puritan

It is often surprising to realize the uncanny similarities in the creative writings of seemingly opposite cultures. In â€Å"The Crucible,, by Arthur Miller, the characters are indulged in their Puritan lifestyle, behaviors and thinking patterns. Yet their struggles are curiously similar to concerns and difficulties evidenced in our own popular culture. Songwriter Billy Joel explores fear, hatred and the ease with which some people go along with the crowd in his song, †An Innocent Man†. In the early lines of the piece, Billy Joel writes: â€Å"If there’s a chance of it opening up, they hear a voice in the hall outside, and hope that it just passes by.† This is sort of a metaphor for Parris in,† The Crucible† and how he blinks when something goes wrong, hoping it will just go away. Further along in an Innocent Man†, Joel sings, â€Å"Some people find that it’s easier to hate, than to wait anymore.† The apparent tendency to hate and fear is a common theme in the Salem Puritan society of â€Å"The Crucible†. Lastly, Billy Joel writes, â€Å"Some people hope for a miracle cure, some people just accept the world as the way it is, but I’m not willing to lay down and die.† This part of the song reminds me of the Republican and Democratic parties and how we voted for the republicans to fight back against the terrorists in the Middle East. The second part of the first verse is a metaphor for Parris and how he just hopes that his problems will go away. In the beginning of the play Parris finds his daughter and niece along with many other girls from the town in the woods dancing around a crock-pot. He tries to look past it and believe that it never happened. Parris does this with many situations in the book. When he finds out that Abigail was fried from the Proctor house. Parris tries to believe that it never happened so that he can go on with his priestly duties. Then after his daughter goes into a trance to disprove the t... Free Essays on Puritan Free Essays on Puritan It is often surprising to realize the uncanny similarities in the creative writings of seemingly opposite cultures. In â€Å"The Crucible,, by Arthur Miller, the characters are indulged in their Puritan lifestyle, behaviors and thinking patterns. Yet their struggles are curiously similar to concerns and difficulties evidenced in our own popular culture. Songwriter Billy Joel explores fear, hatred and the ease with which some people go along with the crowd in his song, †An Innocent Man†. In the early lines of the piece, Billy Joel writes: â€Å"If there’s a chance of it opening up, they hear a voice in the hall outside, and hope that it just passes by.† This is sort of a metaphor for Parris in,† The Crucible† and how he blinks when something goes wrong, hoping it will just go away. Further along in an Innocent Man†, Joel sings, â€Å"Some people find that it’s easier to hate, than to wait anymore.† The apparent tendency to hate and fear is a common theme in the Salem Puritan society of â€Å"The Crucible†. Lastly, Billy Joel writes, â€Å"Some people hope for a miracle cure, some people just accept the world as the way it is, but I’m not willing to lay down and die.† This part of the song reminds me of the Republican and Democratic parties and how we voted for the republicans to fight back against the terrorists in the Middle East. The second part of the first verse is a metaphor for Parris and how he just hopes that his problems will go away. In the beginning of the play Parris finds his daughter and niece along with many other girls from the town in the woods dancing around a crock-pot. He tries to look past it and believe that it never happened. Parris does this with many situations in the book. When he finds out that Abigail was fried from the Proctor house. Parris tries to believe that it never happened so that he can go on with his priestly duties. Then after his daughter goes into a trance to disprove the t...

Definition and Examples of Helping Verbs in English

Definition and Examples of Helping Verbs in English In English grammar, a helping verb is a  verb that comes before the main verb (or lexical verb) in a sentence. Together the helping verb and the main verb form a verb phrase.  (A helping verb is also known as an  auxiliary verb.) A helping verb always stands in front of a main verb. For example, in the sentence Shyla can ride her sisters bicycle, the helping verb can stand in front of  ride, which is the main verb. More than one helping verb can be used in a sentence. For example, in the sentence Shyla could  have  walked to school, there are two helping verbs: could  and have. Sometimes a word (such as not) separates the helping verb from the main verb. For example, in the sentence Shyla does not want a new bicycle,  the negative particle not comes between  the helping verb does, and the main verb want. Helping Verbs in English is, am, are, was, werebe, being, beenhas, have, haddo, does, didwill, shall, should, wouldcan, couldmay, might, must Examples and Observations [Some]  helping verbs  (forms of have, be, and do) may also function as main verbs. In addition, nine  modal  verbs (can, could, may, might, must, shall, should, will, would) function only as  helping verbs. Have, be, and do change form to indicate tense; the nine modals do not. (Walter E. Oliu, Charles T. Brusaw, and Gerald J. Alred,  Writing That Works: Communicating Effectively on the Job, 10th ed.  Bedford/St. Martins, 2010)   I have always hated those upstart space toys.(Stinky Pete the Prospector in Toy Story 2, 1999)If we love our country, we should also love our countrymen.(Ronald Reagan)We can stay up late, swapping manly stories.(Donkey in Shrek, 2001)Nothing great was ever achieved without enthusiasm.(Ralph Waldo Emerson)Life has taught us that love does not consist in gazing at each other, but in looking outward together in the same direction.(Antoine de Saint-Exupery)A pigeon landed nearby. It hopped  on its little red feet and pecked into something that might have been a dirty piece of stale bread or dried mud.(Isaac Bashevis Singer, The Key. The New Yorker, 1970) Functions of Helping Verbs Helping verbs indicate shades of meaning that cannot be expressed by a main verb alone. Consider the differences in meaning in the following sentences, in which the helping verbs have been italicized: I may marry you soon.I must marry you soon.I should marry you soon.I can marry you soon. As you can see, changing the helping verb changes the meaning of the entire sentence. These differences in meaning could not be expressed simply by using the main verb, marry, alone. (Penelope Choy and Dorothy Goldbart Clark, Basic Grammar and Usage, 7th ed. Thomson, 2008) More Functions of Helping Verbs Helping verbs . . . enable us to express various conditions: If he could type, he would write the next great American novel. Helping verbs help us express permission: You may go to the movie. Helping verbs help us express ones ability to do something: She can play golf extremely well. Helping verbs enable us to ask questions: Do you think he cares? Will he win the race? (C. Edward Good, A Grammar Book for You and I Oops, Me!  Capital Books, 2002) How to Use Helping Verbs to Change Active Voice to Passive Voice If the active sentence is in the past tense, then the full verb in the passive version will be as well: Monica groomed the poodle → The poodle was groomed by Monica. 1. Monica moves to the end of the sentence; add by, so prepositional phrase is by Monica.2. The poodle moves to the front into the subject slot.3. Helping verb be is added in front of the main verb.4. Past tense marker jumps off groomed and onto helping verb be.5. Helping verb agrees with new subject (third person singular) was.6. Main verb groomed converts to its past participle form groomed. (Susan J. Behrens, Grammar: A Pocket Guide. Routledge, 2010)

Operations Management and the Operations Manager Essay

Operations Management and the Operations Manager - Essay Example The operations manager is also responsible for the layout of the manufacturing plant and its structure, planning for the project management methods as well as the selection of the right equipment as well as replacement. The operations manager is also responsible for all the operational services such as scheduling and control of production, management of inventory, control and inspection of quality, traffic and handling if materials, as well as formulating and enforcing the implementation of equipment maintenance policies. An operations manager also is tasked with the responsibility of ensuring the smooth operations of various processes that add up to the production of various goods and services of an organization. This individual typically has a lot of responsibilities as he does a bit of just everything. In a bit just to summarize the responsibilities of an operational manager, it is worth stating that he is responsible for logistics management, budget management, operational strategizing, manage support services as well as managing third party relations (Opsman,

Characteristics of Servant Leadership Essay Example | Topics and Well Written Essays - 750 words

Characteristics of Servant Leadership - Essay Example There are distinctly identified characteristics of servant leaders which influence the behavior of individuals, groups and organizations as they make a profound impact to the society in general. This essay would identify two servant leadership characteristics and proffer how these characteristics are used along with collaboration to influence various individuals and groups. In addition, the areas that leaders could focus on, personally, and through their organizations, would be identified to make an impact and improve society. Larry C. Spears, Chief Executive Officer of The Greenleaf Center for Servant-Leadership, has identified ten (10) characteristics of effective, caring leaders. Spears (2006, 2) averred that â€Å"servant-leadership seeks to involve others in decision making, is strongly based in ethical and caring behavior, and it enhances the personal growth of workers while improving the caring and quality of organizational life.† Thereby, he identified the ten characteristics of servant leaders as skills in (1) listening, (2) empathy, (3) healing, (4) awareness, (5) persuasion, (6) conceptualization, (7) foresight, (8) stewardship, (9) commitment to the growth of people, and (10) building community. These characteristics were confirmed in another discourse written by De Graaf, Tilley & Neal (2001, 1) A servant leader characteristic that is critical and relevant in influencing individual members, groups, organizations as they move to impact society in general, is efficient and effective listening skills. A servant leader has genuine interest to determine the needs, feelings, will, and messages of his followers through intent listening. Through listening, the servant leader determines and absorbs the innermost thoughts of his constituents. Since his objective is to solicit active involvement and participation of his followers in decision making processes, listening enables the servant leader to collect inputs from his followers

Advanced Criminalities Assignment Example | Topics and Well Written Essays - 500 words

Advanced Criminalities - Assignment Example The amount (percentage) of ethanol in beer varies depending on brands. The amount (percentage) of ethanol in the beer that the accused can be assumed to be a particular value so that everybody reads the same script given the difference in the percentages of ethanol in beer. iv) The test results showed that the accused was not able to perform some physical activities like standing on one leg as well as walking. It is very wrong to say that the only thing, which can impair one from walking or standing on one leg, is alcohol. There are numerous factors that can make one unable to walk. Health status of a person a significant factor that can deter someone from walking or standing on one leg. The assumption, therefore, is that the accused was of good health. No. One cannot have such high percentage of alcohol in the blood with just four beer. The person must have consumed copious amounts of beer. The percentage of ethanol in the beer was 3.5%. This value is very low and, therefore, four beers cannot result in recording 0.17% blood alcohol level. The person may have consumed four beers as he claims but might have also consumed other additional drinks, which may be responsible for the o.17% blood alcohol level. The range of maximum blood alcohol level at which one is allowed to operate a vehicle on a public road is in most states is 0.5- 0.8 for males and 0.25-0.7 for females. The blood alcohol concentration mostly depends on the gender, the period over which the alcohol was taken, the amount of food present in the stomach, the weight as well as the metabolism rate. However, it is always important to note that in as much as the BAC level of a person can be estimated, the number of drinks, height and weight alone cannot help in determining the BAC. (Zernig, Salaria, Kurz, 2000. Pg. 420) Eight 4-ounce glasses of wine with approximately 12% alcohol content would be required to make the BAC level to be 0.17%.  Ã‚  

Prayer in School Essay Example | Topics and Well Written Essays - 750 words

Prayer in School - Essay Example I think that the government should be focused on the school's academics, not what religion they are to study. The proposed amendments would cause nothing but trouble considering that there would be many arguments on what beliefs should be taught. Religion is private and schools are public. Having any prayer in school goes against the basis in which our country was formed upon. America came into being because colonists wanted religious freedom. Our founding fathers carefully wrote the constitution to grant the freedom of separation of church and state. A prayer created and supported by a government violate the very essence of the spirit in which the US was formed. It was not until 1962, in the case of Engel v. Vitale, that the Supreme Court ruled that the voluntary prayer used to begin the day in New York public schools was unconstitutional. [Paul D. Kauper, 1963] The prayer, created by the New York Board of Regents, read, "Almighty God, we acknowledge our dependence on Thee, and we beg Thy blessings upon us, our parents, our teachers and our country."[Geoffrey R. Stone, 1983] The decision to ban school-sponsored prayer was "so unpopular that many school districts simply have disregarded it."[Greenawalt] In fact, a 1980 American National Election Study found that 72.1% of Americans believe that schools should be allowed to start each day with a prayer.[Kirk W. Elifson and C. Kirk Hadaway] Since the banning of organized prayer in public schools in 1962, the nation has been in steady moral decline. Divorce rates, teen pregnancy, violent crime, and drug use have all increased. Many school prayer supporters believe there is a direct correlation between the removal of prayer from public schools and the decline of morality. Religious conservatives are convinced that religious influence in the schools is necessary to teach students morals and values. Through their rulings, the court has also defined some times and conditions under which public school students may pray, or otherwise practice a religion at any time before, during or after the school-day, as long as your prayers do not interfere with other students. In meetings of organized prayer or worship groups, either informally or as a formal school organization. Before eating a meal at school -- as long as the prayer does not disturb other students. In some states, student-led prayers or invocations are still delivered at graduations due to lower court rulings. [Geoffrey R Stone] However, the Supreme Court's ruling of June 19, 2000 may bring this practice to an end. Some states provide for a daily "moment of silence" to be observed as long as students are not encouraged to "pray" during the silent period. As society goes we have things we would be better suited addressing than whether or not kids get to go to a crusade. Kids seem to have a better handle on it than we adults. If your kid gets out of school two hours to hear a nondenominational sermon why are you concerned There are far worse things for your kid to get out of school for. If your religion does not believe in a God then your kid should be firmly grounded in your faith that he cannot be swayed by listening to this. [Riley M. Sinder & John K. Lopker] Prayers in public school should be allowed as it may inculcate the belief that God exists. In today's world, many are turning out to be infidel and many are following

EARLY JAZZ PIANO STYLES Essay Example | Topics and Well Written Essays - 1500 words

EARLY JAZZ PIANO STYLES - Essay Example With Bennie Moten’s innovation, jazz piano incorporated some blues in it which accounted for the â€Å"blues-rooted modern jazz† (Schuller 4). Gioia’s account brought up the influence of Mexican band performers to the birth of jazz in Kansas City, New Orleans (7). It was during the time when the Louisiana Purchase only resulted to a one-eighth Anglo-Saxon population and the Latin Americans dominated in numbers in the said area (Gioia 6). Decades passed, and the influence of African-Americans grew to be more noticeable with the introduction of rhythm and blues. In fact, modern jazz is described as a hybrid of various Latin and African-American music genres, such as Broadway music, pop, blues, samba, reggae, funk, and other symphony music (Gioia 8). This essay follows the discussion of various musical works in jazz piano and descriptions of each popular jazz work in history. In particular, it discusses the popular Stride Ragtime, specifically the Harlem stride pian o, Boogie Woogie, Earl Hines’ jazz piano pieces, and G. Gershwin’s Rhapsody in Blue. Descriptions of these masterpieces will also be supported by some music authors’ perception of their music for validation and complementary interpretation. Stride Ragtime: Harlem Stride Piano Among the best pianists in New York, four of them were experts in stride playing. James P. Johnson, Luckey Roberts, Willie â€Å"The Lion† Smith and Richard â€Å"Labba Labba† Maclean were among the victors in stride ragtime battle known as â€Å"cutting contests† in which they were known as ticklers (Martin and Waters 108). Stride ragtime is played fundamentally by the left hand which strides â€Å"up and down the keyboard† using a â€Å"base note or an octave played on the first and third beats of the 4/4 measure† while goes on to alternate with a midrange note â€Å"on the second and fourth beats† (Martin and Waters 108). Stride ragtime originate d from ragtime itself but was developed into stride piano using some techniques such as speed, variations, incorporation of blues, and other improvisations that were â€Å"sometimes planned† (Martin and Waters 108). Harlem Stride Piano incorporates speed and flash. The effect appears to be vigorous and full of energy, a mimicry of American society shortly after World War I in which American lifestyle was fast-paced, hectic, and seemingly always in a rush. It also depicts sounds heard in cars and other automobiles, telephones, and airplanes (Martin and Waters 108). It also suggests a pleasing and lively mood because of the seemingly ‘caricature’ accompaniment which is a perfect background to slapsticks and pathos visual shows. Eubie Blake was particularly famous for being a pianist and composer during early, middle, and late 1900s and took the stride ragtime to a new level (Martin and Waters 109). Most importantly, James P. Johnson fathered stride piano by being s o absorbed in his craft through composing jazz pieces for Broadway musicals and concerts and keeping on learning and experimenting for the said genre (Martin and Waters 109). Boogie-woogie â€Å"Noisy offspring† was labeled to another genre of jazz piano, which became an instant hit in the late nineteenth and early twentieth century (Silvester 3). Boogie-woogie came to the existence in 1940s following combination of ragtime and rhythm of African music as evident by the qualities

The accidental investment and Mans search for meaning compared Essay

The accidental investment and Mans search for meaning compared - Essay Example These themes revolve around ethics, morality, values and motivation. Ethics is the differentiation of good and bad and so is morality. Morality however has an aspect that revolves around the background the individual or people have been brought up in and the morals that were instilled in such individuals. It is therefore not a wonder then that in the first book which solely deals with bankers, the author describes in detail how some bankers shamelessly and in most cases surreptitiously swindle their clients finances by lying about investments and especially those made through the internet. The author who was also in that business but later due to the lack of ethics and morality of the colleagues left explains how those bankers are self-centered thinking only about their future and not of those clients. This may be termed as a lack of morality, self-value and even ethics. The theme of motivation in this book becomes evident where it the motivations of the bankers to make ends meet and avoid having a poor future that make them swindle and lie to clients about investments. The same can be said about the second book whose concept of lack of morality, values and ethics revolves around the Nazi soldiers whose lack of the above mentioned themes led to them treating the Jews inhumanely and subjecting them to unbearable torture. It is this torture that made the author of the book decide to introduce a motivator through counseling the rest of the prisoners to keep their hopes and dreams alive and avoid them losing touch and giving up in life despite them being in the concentration camp. In the first book about investment, the author gives first-hand experience of what really goes on in the investment business that the rest of the population do not know are simply too ignorant to understand. The ethics and morality by bankers in the investment business has simply evolved from being that based on truth and deep care for the client to that of making money and generating rev enue regardless of how they will do it. Their values are not in customer satisfaction or benefit like it used to be the case in other previous decades, they simply think about themselves and their future which is uncertain and hence will fleece the innocent investors of their money without flinching an eye. Their motivation relies on internet and it superb working to connect many investors and at the same time remain faceless hence avoiding feelings of guilt in the end. The other book â€Å"Man’s search of meaning† is simply a personal experience about the author’s time spent in Nazi’s concentration camp, the hardships they faced, the inhumane treatment, the lack of morals and values by the guards running the camps and in the end the motivation behind survival in the camps and not giving up hope in spite of all the mistreatment. The theme of the first part of the book is about ethics and morality and how the guards in the concentration camp just like the bankers in the above book think about only themselves and hence step down harder on the rest of the people to achieve their goals and objectives at the end of the day. The motivation in the second part where logo therapy is employed by the author in a bid to keep alive and survive all that is interconnected with the motivation behind the banker’s use of internet to benefit themselves and feel less guilt or sad emotions for what they are doing. 2 How do the themes connect with my own ethics, values, interests and motivators? Ethics enable a person differentiate between the good and the bad and therefore make one avoid or correct the things that are deemed bad by the individual or society and concentrate on the good or work towards the good. The

EARLY JAZZ PIANO STYLES Essay Example | Topics and Well Written Essays - 1500 words

EARLY JAZZ PIANO STYLES - Essay Example With Bennie Moten’s innovation, jazz piano incorporated some blues in it which accounted for the â€Å"blues-rooted modern jazz† (Schuller 4). Gioia’s account brought up the influence of Mexican band performers to the birth of jazz in Kansas City, New Orleans (7). It was during the time when the Louisiana Purchase only resulted to a one-eighth Anglo-Saxon population and the Latin Americans dominated in numbers in the said area (Gioia 6). Decades passed, and the influence of African-Americans grew to be more noticeable with the introduction of rhythm and blues. In fact, modern jazz is described as a hybrid of various Latin and African-American music genres, such as Broadway music, pop, blues, samba, reggae, funk, and other symphony music (Gioia 8). This essay follows the discussion of various musical works in jazz piano and descriptions of each popular jazz work in history. In particular, it discusses the popular Stride Ragtime, specifically the Harlem stride pian o, Boogie Woogie, Earl Hines’ jazz piano pieces, and G. Gershwin’s Rhapsody in Blue. Descriptions of these masterpieces will also be supported by some music authors’ perception of their music for validation and complementary interpretation. Stride Ragtime: Harlem Stride Piano Among the best pianists in New York, four of them were experts in stride playing. James P. Johnson, Luckey Roberts, Willie â€Å"The Lion† Smith and Richard â€Å"Labba Labba† Maclean were among the victors in stride ragtime battle known as â€Å"cutting contests† in which they were known as ticklers (Martin and Waters 108). Stride ragtime is played fundamentally by the left hand which strides â€Å"up and down the keyboard† using a â€Å"base note or an octave played on the first and third beats of the 4/4 measure† while goes on to alternate with a midrange note â€Å"on the second and fourth beats† (Martin and Waters 108). Stride ragtime originate d from ragtime itself but was developed into stride piano using some techniques such as speed, variations, incorporation of blues, and other improvisations that were â€Å"sometimes planned† (Martin and Waters 108). Harlem Stride Piano incorporates speed and flash. The effect appears to be vigorous and full of energy, a mimicry of American society shortly after World War I in which American lifestyle was fast-paced, hectic, and seemingly always in a rush. It also depicts sounds heard in cars and other automobiles, telephones, and airplanes (Martin and Waters 108). It also suggests a pleasing and lively mood because of the seemingly ‘caricature’ accompaniment which is a perfect background to slapsticks and pathos visual shows. Eubie Blake was particularly famous for being a pianist and composer during early, middle, and late 1900s and took the stride ragtime to a new level (Martin and Waters 109). Most importantly, James P. Johnson fathered stride piano by being s o absorbed in his craft through composing jazz pieces for Broadway musicals and concerts and keeping on learning and experimenting for the said genre (Martin and Waters 109). Boogie-woogie â€Å"Noisy offspring† was labeled to another genre of jazz piano, which became an instant hit in the late nineteenth and early twentieth century (Silvester 3). Boogie-woogie came to the existence in 1940s following combination of ragtime and rhythm of African music as evident by the qualities

Rhetorical Strategies Essay Example for Free

Rhetorical Strategies Essay It is noticed that Margaret Atwoods every latest narrative story produce a fastidious enthusiasm as she has looked target on damaging expectations of the readers of what the narrative will be akin to or in other words the perspective. It is not correct in the case of The Blind Assassin that brought prominent Booker Prize for Atwood. The perspectives of the story in the Blind Assassin explode into movement with the provocation of the aspiration for a rationalization of the anonymity articulated in its opening verdict: Ten days after the war ended, my sister Laura drove a car off a bridge. (Atwood, p1) The Blind Assassin prompts its readers that a chief exposure will come as the rhetorical strategy of using perspective of this lengthy story by building a first-person description that make an impression on readers into a contest with Iris Chase Griffen to shape anonymity earlier than she depict the blameworthy gathering. Additionally, in view of the fact that Iris is creating a diversity of confessional chronicle, the reader is animated by the craving to forfeit concentration to the rhetorical device of perspectives which will join Iris to the lady in the story-within-a-story. Iris symbolizes herself as a historian, investigating the proceedings causing her sisters perceptible suicide. Simultaneously, the storyline must be cautious not to create the rhetorical device of perspectives of the clues so apparent that the person who reads misplaces attention by precipitately forming the responds to the mystery aspects of the novel generated in start of the story. The case of Laura Chases suicide is extremely dissimilar seeing from the start Iristhe narratives I who is as well its eye delicately converse the discern rhetorical device of perspective of both what origin the suicide and even who the offender is. The extraordinarily length of the narrative propose that it will be likely in the completeness of time to be acquainted with the reality, but simply by setting up what led up to Lauras abrupt end. The rhetorical device of perspective of the stratagem of The Blind Assassin is deposit in movement by its conclusion, a conclusion that guides to consider Iris is acquainted with the reality however will not expose until the appropriate moment. This is a narrative that a great deal relates to time and rhetorical device of perspective of the story, and about moment of time in the manner that timing is vital to knowing. The rhetorical device of perspectives toward which the story gradually guides could all be completed at the beginning well ahead of this extended story complete it. On the other hand, their rhetorical device of perspective of the truth would be reduced without the slow preparation for the climax. And with the reveal of the climax perspective it is suitable to revolve for a short time to a narratologist whose outlooks elucidate the reading of this story. The Blind Assassin appears to be self intentionally functioning in this male description concept with its storyteller who has a heart, to make use of that traditional expression, and who consequently seems to be contesting in opposition to the perspective of time to finish her storytelling prior to bereavement forecloses the prospect of supplementary life for storytelling. This fact creates a sagacity of deception for the reason that the readers know that Iris has to stay alive to finish the narrative, from the time when she is the solitary survivor of the disaster of a five decades previously. For that reason, the person who reads this narrative turns out to be concerned in the craving of this description to shift rapidly toward its ending, and nevertheless not too rapidly, for the reason that the climax may well be the climax of the storyteller’s life. In this approach the description appears mannish in the sagacity of sketching its readers into the perspective of contradictory requirements to hasten to the culmination and moreover tarry to extend the enjoyment of the narrative. The story makes coating upon coating of craving: the wish to know ultimately why Laura Chase suicide, a wish challenge by the wish of her sister Iris as storyteller to prevent that antagonizes for which in a variety of senses the cost is death. Additionally, it should be kept in mind that Iris is not merely a storyteller but also a writer, even though an unappreciated one. It might also be disputed that this narrative is itself a narrative, expressing description as an illustration of chronicle but also elevating some charming perspectives about narratives. Works Cited Atwood Margaret, The Blind Assassin: a Novel, Anchor (August 28, 2001), 544 pages, ISBN-10: 0385720955

Modernization Theory and Dependence Theory Analysis

Modernization Theory and Dependence Theory Analysis In this day and age the rapid development of the word and the growing assimilation of countries can hardly fail to affect the development of new theories which attempt to explain the relationship between countries and the existing inequality between developed countries and countries of the third world. Two theories which analyze the development in third world countries are the modernization theory and the dependence theory. These two theories, while being rather different, still have several similarities in their views on the modern world and relationships between developed and developing countries. As Alvin So explained, there are three chief and historical essentials which were constructive to the foundation of the modernization theory of development after the Second World War.First, the United States rose as a superpower.While other Western nations, such as Great Britain, France, and Germany, were undermined by World War II, the United States came out of the war stronger then before, and became a world leader with the execution of the Marshall Plan to reconstruct Western Europe.[2]Second, the idea of communist began to move throughout the world.What was once the Soviet Union spread its influence to Eastern Europe, China, and Korea.Third, there was the breakdown ofEuropean colonial empires in Asia, Africa and Latin America, creating numerous new nation-states in the Third World.These budding nation-states began searching for a form of development to support their economy and to improve their political independence. The modernization theorys intellectual lineage has been traced back to Aristotle. Aristotle first recommended that states, just as plants, went through a natural pattern of growth. Just like Aristotle, Americans in the early Republic assumed that if societies grow in a natural manner, they must also perish. The thought that the progression of human development could be understood and controlled dates to the early nineteenth century, when France and Britain were struggling to bring back their trade empires. Since then it has tended to reappear at times and places where systems of dominance required explanation and rationalization. The modernization theory looks at the internal factors of a country with the assumption that, with aid, â€Å"traditional† countries can be developed in the same way more developed countries have. The modernization theory tries to recognize the social variables which cause social growth and development of societies, and then tries to explain the social evolution. In order for a country to have a profitable, sophisticated, modern economy the country must follow a pattern of development. This is a very systematic theory as it means do one thing and another will happen. In order for this to happen, there need to be prerequisites for takeoff that will lead to takeoff in which will lead to mass-consumption(Mahler 45). A missing component of this theory is that the modernization theory assumes all countries will follow the set path to development. There are actually numerous variables in which will affect a states ability to in fact develop. An example of this is the fact that Mexic o is geographically designed in a way that will cause it to have a weak economy due to the deserts, forests, and mountains. This makes it so that only 12% of the land is arable. The fact that there are no major rivers doesnt help either. These issues all help to making it tricky for Mexico to develop because it restrains transportation, which in turn weakens the possibility of exporting and importing goods in a proficient manner.Another problem with the modernization theory is that it assumes that all states have the necessary preconditions to develop. This is not true as many states do not have proper leaders and government. The explanation for this is that if a state is controlled by weak leadership, it will in turn influence its ability to develop. For example, Saddam Hussein, made it so that his country could not develop because he took all of the wealth for himself. Perhaps, if Hussein had spread the wealth throughout his country, this will have helped education and increased i nvention. This could have made it so that his country developed in a more efficient manner. One policy implication the modernization theory suggests is that the third world countries should look up to the developed western nations, while the Western countries should pass on more modern values, institutions, technology, and financial investment to the Third World countries. Another implication is that in order for the third worlds to develop, they should be moving along the path that the United States has traveled, hence move away from the ideas of communism. (READING) A theory in which is opposed to the Modernization model which was created largely as a response to it is the Dependency theory. Dependency theories developed in opposition to the optimistic claims of modernizationtheory which saw the less developed countries being able to catch up with the West. They stressed that Western societies had an interest in maintaining their advantaged position in relation to the LDCs and had the financial and technical wherewithal to do so. A variety of different accounts of the relationship between the advanced and less developed states evolved within the broad framework of dependency theory, ranging from the stagnationism and ‘surplus drain theory of Andre Gunder Frank (which predicted erroneously that the Third World would be unable to achieve significant levels ofindustrialization), to the more cautious pessimism of those who envisaged a measure of growth based on ‘associated dependent relations with the West. The major contribution to dependency theory was undoubtedly that of Frank, a German economist of development who devised and popularized the phrase ‘the development of underdevelopment, describing what he saw as the deformed and dependent economies of the peripheral states-in his terminology the ‘satellites of the more advanced ‘metropolises. InCapitalism and Underdevelopment in Latin America(1969), he argued that the Third World was doomed to stagnation because the surplus it produced was appropriated by the advanced capitalist countries, through agencies such as transnational corporations. Frank himself insisted that growth could only be achieved by severing ties with capitalism and pursuing autocentric socialist development strategies. According to the dependency theory, the Global North exploits the Global South. One reason for this is that the south is highly dependent on the wealth of the north; therefore unable to advance themselves because of the vicious cycle that then ensues. An example of this vicious cycle can begin with a country being very poor and/or economically unstable. They then allow a multinational corporation to set up camp in one of their cities. This leads to many new jobs for this city, but the people are hired for very poor wages. Then the products that are produced get siphoned off by the Global North, in turn preventing that states â€Å"mass-consumption† abilities which is a generalized way that the south gets exploited by the north and the multinational corporation comes out making huge profits at the expense of desperate people just trying to survive and willing to work for pennies. The depencde theory has several implications. First, Promotion of domestic industry and manufactured goods. By imposing subsidies to protect domestic industries, poor countries can be enabled to sell their own products rather than simply exporting raw materials. Second, Import limitations. By limiting the importation ofluxury goodsandmanufactured goodsthat can be produced within the country, the country can reduce its loss of capital and resources. Thrid, Forbidding foreign investment. Some governments took steps to keep foreign companies and individuals from owning or operating property that draws on the resources of the country. In conclusion, both theories admit the leadership of western countries and their currently dominant position in the modern world, while undeveloped countries are characterized by socio-economic and political backwardness. At the same time, the two theories agree that the cooperation between western countries and developing countries is constantly growing and leads to their integration. However, it is necessary to underline that Modernization theory views such cooperation and integration as a conscious and voluntary act from the part of developing countries, for which modernization in the western style is the only way to overcome the existing backwardness, while supporters of Dependency theory argue that such cooperation and integration is imposed to developing countries by more advanced western countries, which simply attempt to benefit from their cooperation with developing countries and their westernization becomes a way of the establishment of control over and growing dependence o f developing countries on developed ones. Regardless, the existing differences, both theories still raise a very important problem of relationships between developed and developing countries and the dominance of western countries and western civilization in the modern world.

Bury My Heart At Wounded Knee :: essays research papers

Bury My Heart at Wounded Knee   Ã‚  Ã‚  Ã‚  Ã‚  The Indians were being confined to crowed reservations that were poorly run, had scarce game, alcohol was plentiful, the soil was poor, and the ancient religious practices were prohibited. The Indians were not happy that they had been kicked off there land and were now forced to live on a reservation. The Indians then began to Ghost Dance a form of religion it is said that if the Indians were to do this trance like dance the country would be cleansed of white intruders. Also dead ancestors and slaughtered buffalo would return and the old ways would be reborn in a fruitful land. Once the Bureau of Indian affairs noticed what was going on they began to fear this new religion would lead to warfare. The white peoplewere scared that this new dance was a war dance. They called for army protection. Army was called in to try to curbed this new religion before it could start a war.   Ã‚  Ã‚  Ã‚  Ã‚   The Sioux band tougher led by Little Big Foot. They were heading to Pine RidgeReservation in South Dakota, when the army stopped them and held them at gun pointovernight. Big Foot’s group contained about 300 people two-thirds of them were women and children. While the soldiers numbered around 500 and were armed with automatic weapons. The next morning when the army began to disarm the Indians a shot rang out then the gun fire began leaving about 200 Indians dead in the snow. Thirty soldiers were also killed in the massacre. The soldiers that lost there lives were most likely killed by their own men in friendly fire. Wounded Knee is said to have been the last battle of the war but it was not so much a battle as it was a massacre. It was in fact the last exchange of fire between the army and the Sioux.

Analysis of Richard Adams Watership Down :: essays research papers

Watership Down In this story, Richard Adams' creates an interesting part of the story when eleven rabbits unite to form a group and flee from their warren, in hopes of avoiding a great tragedy. These rabbits leave their warren without knowledge of why they need to leave their homes. The one thing the rabbits have in common is their faith in Fiver's dreams and visions. Together these rabbits will have to put aside their differences in order to face the danger ahead of them. The newfound friends are led by a young headstrong rabbit named Hazel who tries to lead with courage and wisdom. While the group travels to their unknown destination they encounter problems like wild animals, but with cooperation they get through their problems. An interesting part is how they figure out a way to transport their injured Fiver and Pipkin across the river to escape the dog. Using his brains, Hazels has the idea to ship the two injured rabbits across the river upon a flat piece of wood. When this act had been done, the other rabbits had a new admiration of Hazel. This new admiration was brought upon, when he had to choose to leave injured rabbits behind he refused and thought of idea to help them across, Hazel has shown himself as a competent, caring, and wise leader. Fiver is a small rabbit that seems to have the ability to see future visions. It was because of him that the eleven crusaders left to find a new home. He predicted the destruction of the warren long before it was to happen. His character is very strange, he is constantly looking over his shoulder, maybe expecting a hideous monster. When he does not feel totally at ease he will tremble, bolt, or go crazy. He is a good friend to have around, many times he has saved the group with his extraordinary abilities. He had predicted the destruction of the warren and the freakish lifestyle of Cowslip's warren, another is his dream of Hazel trapped in the ditch. Fiver is a reliable and very valuable asset to this group as a friend and as a seer. Without him the group would have died in the warren and would not have had a chance at all. Another of the main characters is Bigwig, he is strong larger rabbit that was previously a part of the group owsla.

Bullying speech Essay

What does it feel like to wake up in the morning and look forward to a day of teasing and name calling? What does it feel like to be engulfed in a world of negativity? Bullying†¦ Unwanted and aggressive behavior among school aged children involving real or perceived power imbalance. Bullying is no man’s best friend and it shouldn’t be. We see it all around us in our daily lives. All across the United States, this form of victimization has become an infamous trend among scholars. About 3 million out of America’s 21 million students are affected by bullying. That is about 1 student in every 7 students! Numerous people have different perspectives on what bullying is. Some think it means physical hurting while others think it is only emotional hurting. All of these are correct due to the fact that there are different ways one can be bullied. Bullying is unwanted and repeated behavior among students which includes Physical, Verbal, Indirect, social Alienation, In timidation and Cyber Bullying. see more:speeches on bullying Physical bullying is a serious problem it is when one person or a group of people picks on or harasses another person in a face to face confrontational manner. Verbal bullying is the most common form but it is just as bad as the other types. It is when an individual uses verbal language (e.g., insults, teasing, etc.) to gain power over his or her peers. Social Alienation is one type of bullying whereby exclusion is occurring between students due to social differences. The devastating part about this form is that it is not easily recognized as a form of bullying. Intimidation is the acts of making someone feel fearful by using threats. Last but not least, Cyber bullying which happens when kids bully each other through electronic devices. Over 25 percent of adolescents and teens have been bullied repeatedly through their cell phones or the Internet. With the increase in our use of technology, this form of bullying is increasing to higher rates. How can you stop this from happening? How can we put an end to bullying? It’s simple. The best way is NOT ignoring it whenever you see it going on. STEP UP! And be an advocate for your fellow peers that are hurting. Bulling is BAD! And it is up to YOU if you would let it happen when  you see it going on or stop it. experience

Lecture Notes for Bio 106

Reproductive roles Male’s job is to get the sperm to the egg The sperm are specialized to deliver the male’s genes to the egg Female’s job is to produce a gamete (egg) containing the female’s genes Egg is specialized to nourish the embryo Egg is large and contains nutrients Egg must be moved along Female must also nourish and protect the embryo and fetus This is the job of the uterus Male reproductive strategy: Produce millions of gametes and hope that one makes it to the egg Female reproductive strategy: Invest heavily in one gamete and nourish and protect it Egg Cell (Ovum; 1 copy each chromosome) Sperm Cell (1 copy of each chromosome) MEIOSIS (a type of cell division that begins with a cell with 2 copies of each chromosome and ends with 4 cells with 1 copy of each chromosome) FERTLIZATION (Fusion of Egg and Sperm nuclei; creates a cell with 2 copies of each chromosome) Zygote (cell formed by fusion of egg and sperm; has 2 copies of each chromosome; will develop into new individual) Ovary (in female) Testis (in male) 1 Gonads: a. Testes in male b. Ovaries in females 1. roduce gametes Male = sperm Female = ovum or egg join zygote; new individual 2. produce sex hormones testosterone estrogen + progesterone Male Reproductive System Testes located in scrotum why? sperm don't survive well at body temperature is 3-4o F cooler temp kept constant by reflex how? – pass through the inguinal canal before birth hole usually closed over with connective tissue possible problems 1. cryptorchidism failure of the testes to descend if not corrected, results in sterility corrected by surgery or by administering hormones 2. inguinal hernia inguinal canal does not completely close intestine may push into opening correct with surgery more common in men but may occur in women Inside Testes 1. eminiferous tubules about 1000 site where sperm are produced by a process called spermatogenesis produce 100 million+ sperm each day from puberty until death spermatogenesis A. takes place in an orderly progression from the outside edge of seminiferous tubule to inside (lumen) B. involves changes in genetic information and changes in the shape and functioning of cell sperm carry father’s genetic contribution to next offspring body cells have 2 copies of each chromosome (1 from Mom & 1 from Dad) gametes (egg or sperm) can have only 1 copy of each chromosome meiosis = the type of cell division that produces gametes 1 cell with 2 copies of each chromosome Meiosis spermatogenesis 4 cells with 1 copy of each chromosome Sperm Structure 2 designed to deliver male’s genetic contribution to next generation 1.Head – contains male’s genetic contribution to next generation; almost all nucleus 2. Acrosome – a sac containing enzymes to will allow the sperm to digest the outer layers around egg so sperm nucleus can reach egg nucleus 3. Mitochondria – energy to fuel the trip to egg 4. Tail (or flagellum) has contractile fibers for motility; allows the sperm to swim to egg 2. interstitial cells – produce male sex hormone – testosterone Still in testis – between seminiferous tubules Beginning at puberty these cells secrete testosterone They are stimulated to secrete testosterone by LH, a hormone produced by the anterior pituitary gland LH (from anterior pituitary) stimulates the release of testosteroneHORMONES chemical messengers produced by certain glands and released into the blood hormone reaches all cells only cells with a receptor for that hormone can respond a cell responds by doing what that cell does it might divide it might produce a chemical it might increase rate of certain chemical reactions so hormones have different effects on different cells cells without receptors for that hormone cannot respond 3 Cell 1 (with receptor) Effect 1 Cell 2 (with receptor) Effect 2 Hormone Into blood supply throughout body Cell 3 (with receptor) Effect 3 Cell 4 (no rec eptor) No Effect Testosterone causes: development of male reproductive apparatus sperm maturation secondary sex characteristics sex drive (in part) Possible problems with testes Testicular cancer: most common in males 25-30 yrs. more common if testes did not descend after 6 yrs. may be hereditary usually does not cause pain Practice self exam! Feel for small lump Best done after a hot shower Sperm next enter a system of tubes to store and transport sperm 1. pididymis: tube about 20 feet long stores sperm sperm mature here, sperm change size and shape, metabolism changes, sperm become capable of moving but don't yet. sperm moved along by peristalsis (a wave of muscle contraction) 2. vas deferens: sperm duct conducts sperm from epididymis to urethra 3. urethra: conducts sperm to outside of body, also conducts urine but never at same time Accessory Glands: 1. Bulbourethral glands mucous secretion just before ejaculation lubricant? Buffers to adjust pH of urethra 2. Prostate gland secre tes fluid, milky color alkaline activates sperm counteracts acidity of female reproductive tract Possible problems with prostate 1. enlarges in older men difficulty urinating & decreased bladder volume 2. rostate cancer grows slowly can spread detected by: rectal exam and blood test for PSA (prostate specific antigen) 4 3. Seminal vesicles make up most of the volume of semen secretion probably nourishes sperm (contains fructose, vitamin C, amino acids, prostaglandins) Result = semen Semen: secretions of accessory glands and sperm about 1 tsp. per ejaculation, about 20 % sperm Functions: transport sperm lubricate passageways nourish sperm decrease acidity of female reproductive tract Penis: Functions: transfer sperm to female conducts sperm outside body tip is enlarged = glans penis (rich in sensory endings) Mechanism of erection 3 columns of spongy tissue arteries dilate ? increase blood delivery veins close down blood accumulatesErectile Dysfunction = Impotence inability to achieve or maintain an erection common problem many possible causes – both physical and emotional drugs now available to help a man have an erection when he is sexually stimulated (e. g. Viagra, Cialis, Levitra) These inhibit the breakdown of the neurotransmitter that causes the arteries in penis to dilate arteries are dilated longer increases and prolongs blood entering the penis ? erection Female Reproductive System gonads = 2 ovaries 1. produce eggs or ova (singular = ovum) egg is specialized to provide nourishment for early embryo large cell full of nutrients 2. produce female hormones: estrogen progesterone Female also nourishes and protects the developing embryo and fetus = job of the uterus 5 Ovarian Cycle = series of events in the ovary that leads to production of egg, estrogen & progesterone 1. ollicle maturation primary follicle = an immature egg surrounded by a layer of follicle cells as follicle matures the immature egg gets larger follicle cells divide and form many lay ers around egg follicle cells secrete estrogen mature follicle egg completes first meiotic division layers of follicle cells splits forming a central cavity filled with fluid containing estrogen egg pushed to side with layer of follicle cells 2. ovulation = release of immature egg from ovary egg released with layer of follicle cells around it rest of follicle cells stay in ovary 3. corpus luteum forms from follicle cells remaining in ovary corpus luteum secretes estrogen and progesteroneOVARY primary follicle (immature egg surrounded by follicle cells) mature follicle (many layers of follicle cells, fluid filled cavity, egg surrounded by follicle cells) after ovulation follicle cells remaining in ovary become corpus luteum estrogen progesterone egg 1. estrogen maturation of egg development and maintenance of reproductive structures cell division: thickens lining of uterus also occurs in breast tissue secondary sex characteristics pubic hair armpit hair broader pelvis breast developm ent 2. progesterone prepares uterus for egg implantation maintains pregnancy 6 Oogenesis = the process by which an egg (ovum) is formed Meiosis: starts with a cell that has 2 copies of every chromosome ends with up to 4 cells with 1 copy of every chromosome 1 egg (ovum) and 3 non functional polar bodies IN FEMALES MEIOSIS IS NOT A CONTINUOUS PROCESS Preparations begin efore birth in all potential eggs Then development stops Beginning at puberty, 1 egg continues to the next stage of development The egg is ovulated (released from the ovary) Meiosis is completed ONLY if the egg is fertilized) Number of ova At puberty: potential for about 400,000 eggs Usually 1 each month develops in each monthly cycle (if 2 form and both are fertilized get fraternal twins) total egg production ~ 450 eggs in lifetime menopause – rest of potential eggs have degenerated Oviducts (Fallopian tubes tubes that conduct the egg to the uterus – takes about 3 days open end enlarged and fringed †“ increased surface area for catching egg cilia line oviducts to help move egg along fertilization – usually in upper third of oviduct ectopic pregnancy – usually a tubal pregnancy early embryo implants and begins development at site other than uterus usually in Fallopian tube (oviduct) dangerous to mother – must be terminated Uterus provides nourishment & protects the developing embryo and fetus A. Cervix – tubular portion the extends into vagina has opening through which sperm enter and baby exits B. Body – region in which fetus develops 1.Endometrium – lining site where embryo implants built up each month cell division makes it thicker becomes more vascular (more blood vessels) glands develop that provide nutritious material then lost as menstrual fluid (woman gets her period) 2. muscle allows uterus to expand as fetus grows 60X bigger at full term pregnancy 7 provides force to push baby out Possible problems with uterus: 1. Pelvic Infl ammatory Disease (PID): any bacterial infection of pelvic organs especially uterus, oviducts, ovaries; may spread (peritonitis) may be painful or chronic may have no symptoms often leaves oviduct scarred so that fertility is reduced and the risk of ectopic pregnancy is increased treated with antibiotics most commonly caused by sexually transmitted bacteria the bacteria that cause gonorrhea and chlamydia 2.Cervical cancer: involves external surface of cervix detect with PAP test risk factors -intercourse at an early age -multiple sex partners associated with certain STDsparticularly the HPV (human papilloma virus) that causes genital warts use of condoms and/or diaphragm decreases risk Vagina ~3 muscular passageway to uterus elastic – expands to allow baby through possible problem with vagina: vaginitis most commonly yeast (Candida albicans) not usually sexually transmitted not from poor hygiene bacteria in the vagina produce acid Anything that kills the bacteria or makes the vagina less acidic allows yeast to grow ? vaginitis Clitoris †¢ †¢ †¢ Derived from same embryological structure as the glans penis Becomes engorged with blood during sexual excitement No known function other than pleasure 8Menstrual or Uterine Cycle the endometrium (uterine lining) is built up to nourish the embryo and then it breaks down and is lost as menstrual flow it is a cycle caused by interplay of hormones want the uterus ready to receive embryo if there is one the ovarian cycle that produces the egg must be coordinated with the uterine cycle that prepares the uterus done by same hormones Hormones of the menstrual cycle OVARY Estrogen – from follicle cells in ovary and later from corpus luteum maturation of egg cell division in endometrium (uterine lining) cell division in breast tissue Progesterone – from corpus luteum further development of endometrium maintains endometrium ANTERIOR PITUITARY FSH – follicle stimulating hormone: stimulate s development of follicle LH – luteinizing hormone formation of corpus luteum from follicle cells remaining in ovary maintains corpus luteum Negative Feedback X? Y hormone X leads to an increase in hormone Y Y? X hormone Y causes decrease in hormone X when hormone X levels fall, less hormone Y produced less hormone Y means less inhibition of hormone X hormone X increases and stimulates release of hormone Y IN GENERAL FSH & LH stimulate release of estrogen and progesterone estrogen and progesterone inhibit release of FSH & LH BUT rapid rise in estrogen triggers LH release LH causes corpus luteum to form and secrete estrogen and progesterone corpus lutuem degenerates – estrogen and progesterone levels drop (removes inhibition of FSH) 9Negative feedback in menstrual cycle Low levels of estrogen and progesterone stimulate the release of FSH (and LH) from anterior pituitary FSH stimulates estrogen release by follicle cells in ovary Estrogen (and progesterone) inhibit FSH (a nd LH) release FSH and LH levels drop Estrogen and progesterone levels drop if the egg is fertilized corpus luteum is maintained by a hormone from the embryo called: human chorionic gonadotropic (HCG) hormone for about 5 months the corpus luteum secretes progesterone placenta eventually takes over progesterone secretion progesterone is needed to maintain endometrium if progesterone secretion stops – there is a miscarriage Menopause considered to have occurred when there is no period for 1 year follicles in ovary spontaneously degenerate eggs no longer produced ends child-bearing years estrogen & progesterone no longer produced in ovary occurs most often between 4555yrs. occurs gradually Perimenopause = time leading up to menopause Symptoms hot flashes & dizziness – dilation of arteries in top half of body may be: irritable headaches fatigue physical changes skin drier & less elastic ? wrinkles breasts decrease in size might be change in distribution of hair osteoporosi s – decrease in bone density NEED NOT CHANGE SEXUAL DESIRE 10Estrogen DESIRABLE EFFECTS Brain regulates areas that prepare for reproduction maintains stable body temperature may protect memory Breast Breast programs glands promotes breast to produce milk cancer Liver & Heart helps regulate cholesterol production prevents atherosclerosi s Uterus Uterus programs uterus to promotes nourish fetus cancer of cell division in endometrium endometrium NEGATIVE EFFECTS Estrogen’s Effect on Bone Bone maintains density causes calcium to be absorbed from gut promotes calcium deposit in bones Osteoporosis – decrease in bone density calcium salts make bone hard bones are constantly remodeled built up & broken down in response to stress (weight or pressure) until age 35 more build up than break down peak bone density influenced by: sex race size nutrition exercise that puts weight on bones overall health Bone Formation Blood level Of calcium Calcium in Bone 11Bone Breakdown Die t influences level of calcium in blood good sources of calcium: milk and milk products (choose low fat) dark green vegetables nuts seeds Weight-bearing exercise stimulates bone formation in the bones that are stressed by the exercise walking jogging calcium levels are regulated by hormones calcitonin from thyroid gland causes calcium to be put into bones parathyroid hormone from parathyroid glands causes calcium to be removed from bone estrogen helps absorption of calcium from digestive system stimulates bone formation After menopause estrogen levels greatly decrease Bone Formation Calcitonin Estrogen Blood level Of calcium Calcium in BoneThe Breast Function To produce milk to nourish the young Structure The breast is composed almost entirely of fatty tissue and milk glands milk glands are called lobules each gland drains into a system of ducts these empty into a collecting chamber below nipple several ducts collect into one duct ducts drain through nipple Possible Problems 1. Preme nstrual tenderness breast tissue is prepared each month along with egg and endometrium Estrogen causes cell division in breast tissue Progesterone causes increase in glandular activity Increase in blood supply to breast swelling and tenderness Parathyroid Hormone Bone Breakdown Bone Formation 12 2. fibrocystic breast disease (disorder) an exaggeration of monthly changes in breast tissue built up tissue is not completely reabsorbed and forms cysts feels like many lumps in breast 3. fibroadenoma – noncancerous lump in breast usually in upper & outer quadrant small moveable lump 4. reast cancer will return to this after discussion of cancer 13 Cancer = uncontrolled cell division Cancer cells kill by: depriving other cells of nutrients preventing other cells from performing their duties blocking important pathways (air, blood, nerve) Cells divide Tumor Benign tumor: stays in one place; not cancer Malignant tumor: cancer, cells spread (metastasize) multiple tumors form in other pa rts of body usually spread via blood vessels or lymphatic system In healthy person cell division is regulated Cell Cycle = the orderly sequence of events in the life of a dividing cell G1 – cell growth (G1 checkpoint – is the cell large enough to divide? S (synthesis) – genetic material (DNA of chromosomes) is duplicated G2 – growth and final preparations for cell division (G2 checkpoint – is the DNA replicated? ) Cell division Mitosis – nucleus divides Cytoplasm divides produces two daughter cells Normal controls on cell growth regulate cell division to allow growth and replacement 14 Cancer cells escape controls Normal controls: 1. Genes regulate the cell cycle GENE carries the instructions for making a protein PROTEIN has a job in the cell it might form (part of) a structure it might be regulatory = determine whether a certain cellular process will occur mutation = change in the gene’s information changes the instructions for the p rotein the new protein might not function or might function differently Normal Controls on Cell Division 1.Genes regulate the cell cycle proto-oncogene – normal form of a gene that produces specific proteins that stimulate the cell cycle for growth and repair acts like accelerator about 60 known if other controls were faulty it would enhance the growth of a tumor tumor-suppressor gene – normal form of a gene that produces specific proteins that slow the cell cycle proteins stop cell cycle at one of the checkpoints acts like brakes Normal Genetic Controls on Cell Division tumorprotosuppressor oncogene gene slows stimulates cell division mutations in these cell cycle genes can cause the cell to lose control over cell division Cancer oncogene = mutant protooncogene over stimulates cell division = stuck accelerator can help induce cancer dominant mutation – only need 1 of the 2 copies to be mutant mutant tumor-suppressor gene impairs ability to slow cell cycle = bro ken brakes enhances tumor formation recessive mutation – need mutation in both copies of the gene to have an effect 15 p53 a tumor-suppressor gene detects damaged DNA 2. rogrammed cell death occurs when genes are damaged cancer cells have mutation in other genes that prevent the damaged cells from being destroyed 3. limited life span cell can only divide 50-60 times telomeres – protective pieces on tips of chromosomes end of telomeres shaved off with each cell division telomerase = enzyme that makes telomeres not present in normal cells is present in most cancer cells 4. Need for blood supply controls prevent new blood supply to tissue unless it is damaged cancer cells produce growth factors to attract new blood vessels blood vessels needed to bring nutrients and remove waste also provides route for cancer cells to spread tops cell division initiates DNA repair if too much DNA damage —> p53 triggers programmed cell death Development of cancer need several mutati ons in same cell before cancer starts leukemia – may be as few as 3 mutations colon cancer – may need as many as 9 mutations EXAMPLE ONLY: Development of colon cancer 1. Loss of tumor-suppressor gene from chromosome 5 a polyp forms on colon wall a benign, precancerous tumor grows 2. Activation of oncogene from chromosome 12 a class II adenoma (benign) forms) 3. Loss of tumor-suppressor gene from chromosome 18 a class III adenoma (benign) grows 4. loss of tumor-suppressor gene from chromosome 17 a carcinoma (malignant tumor) forms 5. other changes ? cancer spreads to other tissues 16 5.Need for cell attachment normal cells must be anchored in place oncogenes produce proteins that break anchors but signal cell that it is anchored Immune System – The body’s defense system cells of the immune system roam the body looking for cells they don’t recognize as belonging cancer cells have changed and are not recognized as belonging if cells of the immune syst em encounter a cancer cell, they will be destroy it Factors that can cause cancer 1. carcinogens = chemicals that cause cancer cause mutations that lead to cancer many mutate p53 stimulate cell division (e. g. estrogen) inhibiting the immune system may be in environment, in food or drink, or inhaled at least 50 carcinogens some carcinogens are only carcinogenic after modification in the body 2. iruses consist of genetic information (usually DNA) inside a protein coat virus enters cell and uses host cell machinery to make new viruses viral DNA is inserted into host cell chromosome and is replicated with host cell DNA viral DNA is then a permanent part of host cell chromosome – it has transformed the cell into a cancer cell – all daughter cells will have the viral genes viruses have oncogenes that produce proteins that stimulate cell division viral protein produced may be hyperactive in stimulating cell division OR viral gene may direct human gene to produce too much of a protein that stimulates cell division result is a host cell that has been permanently changed by virus so that it contains an oncogene that stimulates cell division 3. radiation interacts with DNA and causes mutation ultraviolet (uv) radiation from sun causes skin cancer ionizing radiation natural sources (cosmic rays, radioactive materials in earth’s crust) medical sources (x-ray exams) 17 Risk Factors 1. revious breast or other form of cancer Breast Cancer most breast lumps are benign (not cancerous) fibrocystic breasts fibroadenoma death rate from breast cancer has been declining due to early detection practice monthly self exam breast cancer usually begins in the ducts (80%) or the glands begins as lump or tumor lump is usually in upper outer quadrant staged by size of lump and how far it has spread it can metastasize: break out of this site and spread to fatty tissue or other parts of body through lymphatic system or blood supply to determine whether cancer has spread they would look at sentinel nodes (first lymph nodes to which a tumor drains) 2. Gender females much more likely (men can get breast cancer) 3. Age chance of breast cancer goes up with age rises sharply after 40 4.Family history risk is 2X if: first-degree relative (mother, sister, daughter) with breast cancer risk is 5X if: 2 first-degree relatives with breast cancer may have inherited genes e. g. BRCA 1 or BRCA 2 these greatly increase chance of breast cancer BRCA 1 = a tumorsuppressor gene turns off another gene that blocks cell cycle 18 5. Hormone history prolonged, uninterrupted exposure to estrogen increases risk estrogen stimulates cell division in breast if too much estrogen some believe it can lead to cancer some types of breast tumors are stimulated to grow by estrogen more menstrual cycles = more exposure to estrogen risk increased by: a. early puberty – before 11 b. late menopause – after 55 c. not having children or delaying first pregnancy – after 30 What about other sources of estrogen? irth control pills – probably not hormone replacement after menopause – slight environmental sources – unknown certain pollutants mimic estrogen (pesticides, ingredients in plastics) electromagnetic fields can boost body’s production of estrogen 6. Obesity fat cells produce a substance that is converted to estrogen 7. Alcohol alcohol increases level of estrogen interferes with use of folate, which protects against tumor growth 19 Birth Control Effectiveness rate = # of couples out of every 100 using that means of contraception for 1 year who do NOT become pregnant Failure Rate = # of couples out of every 100 using that means of contraception for 1 year who DO become pregnant Typical Use = average person, use may be improper or inconsistent Vs.Perfect Use = proper and consistent use Effectiveness in Preventing STDs STDs spread by contact (direct contact is usually needed) Infected surface surface Uninfected Effectiv eness in Preventing Pregnancy Highly Effective 1. Sterilization (tubal ligation or vasectomy) prevent sperm from reaching egg 2. Hormonal Contraception A. Estrogen and progesterone – prevents egg development and ovulation 1. oral – the pill 2. vaginal ring – NuvaRing – woman inserts the ring so that it encircles the cervix worn 3 weeks, removed for the 4th 3. skin patch – OrthoEvra new patch once a week for 3 weeks 4th week no patch B. Progesterone-only contraception interferes with fertilization and implantation Types a. ral – mini pill (not used much in US) b. implants c. injections C. Emergency contraception – ? morning after pills? 1. Preven – estrogen and progesterone 2. Plan B – progesteroneonly first dose within 120 hours (5 days), second dose 12 hours later Decrease spread of STDs Certain means of contraception also prevent contact between body surfaces Condom – male or female Diaphragm or cervical cap (so me protection to woman) Increase spread of STDs Pill may increase woman’s risk of certain STDs Spermicides increase a woman’s risk of getting an STD from an infected partner; damages vaginal lining 20 3. IUD – interferes with fertilization and/or implantation; dislodges embryo 4.Diaphragm, cervical cap, FemCap, or Lea’s shield with spermicide – covers cervix and prevents sperm from reaching egg 5. Condom – prevents sperm from reaching egg 6. Vaginal sponge Moderately Effective 1. Spermicides – kill sperm Foams are best is used as only means of contraception May increase the risk of STD spread, particularly in women 2. Rhythm Method – abstinence on all days that could result in sperm meeting an egg Unreliable 1. Withdrawal (coitus interruptus) Does not work 1. Douching after intercourse 2. Intercourse standing up or in some other position 3. Intercourse during menstruation (during your period) 4. Intercourse while breastfeeding Reliable methods 1.Sterilization — permanent birth control Tubal ligation or vasectomy prevent the sperm from meeting the egg Should NOT be used if you or your partner may change your mind For male = vasectomy Close off vas deferens so sperm can’t leave the male’s body Sperm reabsorbed Still ejaculate Simple operation No effect on masculinity No effect on sex life or sex drive Risks: minimal Less than 1% of time tubes grow back together Occasionally a little bleeding in scrotum For women = tubal ligation = have tubes tied Close off oviducts (fallopian tubes) More difficult procedure than a vasectomy because must enter the abdominal cavity Does not cause menopause Will still menstruate No effect on sex drive 21 2. Hormonal Contraception A. Estrogen and progesterone – prevents egg development and ovulation 1. oral – the pill 2. aginal ring – NuvaRing – woman inserts the ring so that it encircles the cervix; worn 3 weeks, removed for the 4th 3. skin patch – OrthoEvra new patch once a week for 3 weeks; 4th week no patch expect same risks as pill, but know most about birth control pill Contain estrogen and progesterone Estrogen & progesterone inhibit FSH and LH Without FSH the egg doesn’t develop Without LH ovulation cannot occur Almost 100% effective – if used properly If you miss more than one day, use another form of birth control Side Effects Headaches Breast tenderness Weight gain Vaginal Infections are more common Serious Risks caused primarily by estrogen Circulatory System Problems rare but can be fatal A.Problems: (1) High blood pressure (2) Increased tendency to form blood clots (1) High blood pressure Increases with time on pill Increases with woman’s age STOP SMOKING – cigarette smoking also causes high blood pressure Blood pressure = pressure exerted by blood on vessel walls Created by beating of heart Pressure must be great enough to move blood around the body If too g reat = high blood pressure Problems caused by high blood pressure 1. strains the heart and blood vessels 2. can lead to an aneurysm (weak spot in artery wall balloons out; can rupture; bleed to death internally 3. promotes atherosclerosis (fatty deposits in arteries) and arteriosclerosis (hardening of arteries) 4. amages kidneys; can lead to kidney failure 22 (2) Increased tendency to form blood clots Danger is that a blood clot can break free and lodge in a small blood vessel, blocking blood flow B. Consequences: (1) Increased risk of heart attack and stroke Heart attack = death of heart cells Stroke = death of nerve cells in brain Heart attack & stroke occur when blood flow to heart or brain is interrupted by: Burst vessel Fatty deposits (atherosclerosis) Blood clot (2) increased risk of pulmonary embolism 2. Increased risk of urinary tract infections 3. Increased susceptibility to sexually transmitted diseases A. Change in pH of vagina – increased risk of chlamydia and gon orrhea B.Change in cervical structure exposes vulnerable cells C. HPV (human papilloma virus that causes genital warts) infection is more likely to result in cervical cancer Progesterone seems to activate HPV in cervical cells grown is culture Non-contraceptive benefits of the pill Decreased risk of PID (pelvic inflammatory disease) Decreased risk of ovarian and endometrial cancer Decreased risk of ectopic pregnancy Decreased risk of iron deficiency anemia 1. 2. 3. 4. 2. Hormonal contraception (cont. ) B. Progesterone-only contraception interferes with fertilization and implantation Types a. oral – mini pill (not used much in US) b. implants –hormone containing rods implanted in upper arm c. njections – DepoProvera injection every 3 months 99% effective in preventing pregnancy no protection against STDs 23 Mechanism of action of progesterone only a. Thickens cervical mucus b. Interferes with movement of sperm c. makes implantation more difficult because endometr ium thin d. Sometimes blocks ovulation e. Makes the corpus luteum degenerate too quickly (removes the source of progesterone that maintains the endometrium) Side effects a. Menstrual cycle disturbance Periods irregular More days of light bleeding Missed periods b. Weight gain c. breast tenderness d. bone density decreases 2. Hormonal contraception (cont. ) C. Emergency contraception – â€Å"morning after pills† 1. Preven – estrogen and progesterone 2.Plan B – progesteroneonly first dose within 72 hours, second dose 12 hours later Emergency contraception is thought to work by inhibiting or delaying ovulation preventing fertilization altering the endometrium, making it an inhospitable place for implantation of the young embryo used after an act of unprotected intercourse if pregnancy not desired risk of pregnancy varies from 0 – 26 after a single act of intercourse – depending on day of cycle morning after pill decreases the risk of pregnancy by 75% (e. g. from 26% to 6. 5%) does not affect the embryo is it has already implanted Side effects: 1. nausea in 50-70% of women 22% vomit 2. menstrual cycle disturbance next period 2 – 3 days early or late 3.IUD (intrauterine device) – interferes with fertilization and/or implantation; dislodges embryo Small device placed inside the uterus by physician remains effective for 1, 3 or 7 years, depending on the type 24 Effectiveness 97% with progesterone 99% with copper Mechanism of action of IUD– affects: Sperm – immobilizes sperm; interferes with their movement Ovum – speeds up movement to uterus Fertilization inhibited Endometrium – not properly developed for implantation FemCap – 3 sizes, latex free, removal strap Prevents the sperm from reaching the egg Must use with spermicidal cream or jelly Helps seal gaps Holds it in place Added chemical protection Must be fitted by a health care professional so seal is tight refit if weight c hanges by more than 10 lbs. Effectiveness 97-98% perfect use 81% typical use It is ? at the time? rotection In place not more than 2 – 3 hr before intercourse Left in place at least 6 – 8 hrs. after intercourse Offers the woman some protection against STDs Risks with diaphragm – minimal 1. slight increase frequency of bladder infection 2. possible allergic reaction 3. toxic shock syndrome don’t leave in place more than 24 hours or use when you have your period 1. 2. 3. 4. Disadvantages 1. if never had children, insertion is painful 2. may have heavier menstrual flow & more cramps 3. body may reject it – then not protected against pregnancy Risks 1. pelvic inflammatory disease – primarily following insertion of the device can lead to sterility and increased risk of ectopic pregnancy 2. increased risk of ectopic pregnancy 4.Diaphragm or cervical cap with spermicide – covers cervix and prevents sperm from reaching egg Soft rubber cup on flexible ring that fits over the cervix Lea’s shield one-size fits all reusable device 25 5. Condom – prevents sperm from reaching egg A. Male condom Thin strong latex sheath that covers the penis and prevents sperm from reaching the egg Disadvantages: Must be placed on an erect penis – before contact with vagina Decreased sensation Failures usually due to tearing if pulled on too tightly – leave at tip if too little lubrication Penis should be withdrawn from vagina while still erect B. female condom Pouch of polyurethane with a flexible ring at each end Effectiveness in preventing pregnancy — 74% typical use Effectiveness against STDs Little known Does provide a barrier Male condom still better 6.Vaginal sponge use: put in place before intercourse (moisten first) leave in place for at least 6 hours after intercourse effective for 24 hours works by: 1. creating a barrier to sperm 2. trapping sperm in sponge 3. spermicide to kill sperm effectivenes s: about 83% less if you have had children Moderately Effective 1. Spermicides – kill sperm Foams are best is used as only means of contraception Effectiveness in preventing pregnancy – about 80% for 60 min. Increases a woman’s risk of getting an STD from an infected partner; damages vaginal lining 26 2. Rhythm Method – abstinence on all days that could result in sperm meeting an egg Egg Can be fertilized for about24 hr. after ovulation Ovulation ccurs 14+/days before the onset of flow Sperm Can live for at least 2 days within woman’s body Problem is predicting ovulation 2 days before it occurs Effectiveness about 75% Fertile period Subtract 14 days from cycle length Add 2 days on either side for uncertainty in time of ovulation Earliest fertile day = 2 days before earliest expected day of ovulation Latest fertile day = 1 day after the latest expected day of ovulation Works best if you avoid all days until at least 1 day after you know ovulation ha s occurred Ways of detecting ovulation 1. Body temperature Requires a special thermometer Must be done first thing in the morning When body temperature increases slightly and stays up ovulation has probably occurred 2. cervical mucus cervical secretion is more slippery and thinner at ovulation Unreliable 1. Withdrawal before ejaculation (coitus interruptus) Methods that DON’T work 1. Douching after intercourse 2. Intercourse standing up or in some other position 3. Intercourse during menstruation (during your period) 4. Intercourse while breastfeeding 27Sexually Transmitted Disease (STD) and Sexually Transmitted Infection (STI) Extremely Common 2/3 of cases in people under age 25 More likely to affect women Women exposed greater surface area of mucous membrane during sexual contact Women less likely to know they are infected Infected area not easily seen Urethra less likely to be infected So less like to be pain Therefore, women more like to have serious consequences. Spread by contact (direct contact is usually needed) Infected ? Uninfected surface surface Mucous membranes are most vulnerable linings of: Urethra Vagina, uterus, fallopian tubes Vulva (external genitalia of woman) Mouth and throat Rectum Eyes Many STDs can enter through break in skinBacteria A bacterium is a single cell A bacterium can divide very rapidly producing two daughter cells results in very rapid (exponantial) growth of the population *Bacteria produce harmful chemicals = toxins (poisons) of enzymes these toxins kills or damage body cells the damage to body cells causes the symptoms of the disease Bacteria ? Toxin or Enzyme ? Damages / Kills Body Cells Bacteria divide rapidly ? More Cells? More Toxin (or enzyme) ? More damage to body. * Sometimes the damage or symptom is caused by the body's defense mechanisms against the disease. Bacteria = cells with a slightly different structure than the cells found in your body Bacteria have a cell structures (called ribosomes) that have a sliightly different structure than human version Structural differences are important because they allow antibiotics to bactieria without killing host (your) cells. 28Antibiotics kill bacteria by: preventing bacteria from making cell walls OR preventing bacteria from making complete proteins OR damaging the plasma membrane Bacteria can become resistant to antibiotics by: inactivating the antibiotic pumping the antibiotic out of cell devoloping the ability to function in spite of antibiotics Antibiotic – resistant bacteria are a major health threat Antibiotic Resistance Some bacteria are now resistant to every known antibiotic Bacteria get their resistance from genes that: Inactivate the antibiotic Pump the antibiotic out of the cell Allow them to function in spite of antibiotic How do bacteria get these resistance genes? 1. They can get their own genes through mutation and selection a. mutation rate is high because rate of cell division is high hen antibiotics are used that a re not strong enough or are not used long enough, the most resistant survive each time antibiotic taken improperly, the more resistant bacteria survive resistance builds b. the â€Å"good bacteria? are killed by the antibiotic† the resistant bacteria can reproduce faster than normal, healthful bacteria and cause illness 2. Bacteria can get resistance genes from other bacteria through plasmids that carry genes for resistance Plasmids – a small circular piece of DNA (genetic materal) that contains a few genes not necessary for bacteria to live, but bacteria with them often have an advantage can be inserted into bacterial chromosome and come out as circular piece again Plasmids can be copied and a copy gived to another bacterium through sex then both bacteria have the genes on the plasmid. 29Certain plasmids (called R factors) have genes for resistance to antibiotics possible to have genes for 1 or 10 different antibiotics genes for resistance for one antibiotic can be ad ded to a plasmid than has genes for resistance to other antibiotics leads to the development of bacteria that are resistance to many different antibiotics multi-drug resistance tends to happen in places where antibiotic use is heavy hospitals farm animals Resistance develops where antibiotics used most Hospitals Livestock Overuse and Misuse of antibiotics has led to resistance 1. Misuse for medical purposes Don't demand antibiotics for viral diseases – they don't work on viruses Take the full course of your prescription 2.Widespead use in livestock and agriculture Used in livestock to promote growth Resistance genes can spread from the animals to the bacteria that harm humans Cook meat throroughly (be sure meat juices don't come in contact with other food) Wash fruits and vegetables Avoid raw eggs Chlamydia and Gonorrhea Caused by different bacteria but have similar symptoms Both primarily affect mucous membranes Most noticeable symptom – if it occurs – is pain during urination This occurs if urethra is infected Urethra is more likely to infected in a male Therefore males more likely to have symptoms Often they don't cause symptoms Can still spread the cactiria to others Bacteria still damage reproductive structures 30Chlamydia (Chlamydia trachomatis) Most common bacterial STD in US Highly contagious Symptoms – slow to appear, 3 weeks to months Men More likely to have symptoms than women Painful urination Discharge from urethra Women If urethra is infected Painful urination Discharge from urethra PID (chlamydia causes 50-90% of PID) Slight vaginal discharge Pain during intercourse Abdominal pain & fever Chlamydia is the STD the most likely to cause scar tissue to form in the tubes that gametes move through Because of scar tissue: Chlamydia is the STD most likely to cause sterility Chlamydia is the STD most likely to increase the risk of an ectopic pregnancy The bacteria that cause chlamydia Must live within a cell because they canno t generate their own ATP They use the ATP that the host cell produces Energy in food ATP Energy for cell activities Effects on Fetus in Utero can cause membranes to rupture can cause death of fetus contracted during birth blindness pneumonia infection of mouth, throat, rectum Diagnosis Urine test for DNA for Chalmydia Swab cervix (women) or urethra (males) and culture cells Pap test (women) Treatment: Antibiotics Gonorrhea Caused by diplococcus bacterium Neisseria gonorrheae Symptoms Often none Men More likely to have symptoms than women Painful urination Discharge from urethra 31Women If urethra is infected Painful urination Discharge from urethra PID Slight vaginal discharge Pain during intercourse Abdominal pain & fever Acidity decreases if on pill or at menopause Effect on fetus: Contracted during birth May cause blindness Diagnosis: Urine test form DNA Swab cervix (women) or urethra (males) and culture cells Look for bacteria in cells Treatment: Antibiotics New varieties are re sistant to antibiotics Syphilis Cause = bacterium (Treponema pallidum) Requires a warm, moist environment Can invade any mucous membrane Usually in the genital area Three Stages 1. Primary Stage 2-6 weeks after contact chancre forms may be small swelling or deep lesion usually hard raised edges â€Å"crater-like† painless at site of contact heals by itself in 4-6 weeks diagnosis at this pint is by isolation of the bacterium from chancre 2.Secondary Stage 2-10 weeks after chancre appears Symptoms Rash- doesn't itch, ulcerates Ulcers in mucous membranes In mouth, vulva, vagina, rectum Warly growths around anus and genital organs Headache Body ache May have: Sore throat Gastrointestinal upset Loss of hair Diagnosis at this stage: Blood test that looks for antibodies (VDRL) 32 3. Tertiary Stage 8-25 years after initial contact almost any organ can be infected and develop lesions called a gumma most common sites of gummas: 1. large arteries decrease diameter of artery aneurysm â⠂¬â€œ weak spot in artery that balloons out 2. brain & spinal cord Blindness Deafness Paralysis Mental degeneration 3.Skeleton Effect of fetus Transferred across placenta Can cause deformities Can be fatal Treatment: Early stages curables with antibiotics Virus Viruses have genetic material (usually DNA but some have RNA) and a protein coat (capsid) Structure of a typical virus Steps in Viral Life Cycle 1. Attachement – Viral protein binds to receptor on host cell 2. Penetration – virus enters host cell 3. Biosynthesis – viral genetic material replicated by using host cell ? machinery;? new coat proteins made 4. Assembly – newly synthesized viral compnents put together to form new viruses 5. Release [called viral shedding or budding]; viruses leave cell with envelopes from host cell OR Viruses genetic information can be integrated into host cell chromosome and stay there in dormant form until it is reactivated Viruses can cause call damage as they are rel eased (shed) 1.Rapid release – cell can rupture and die 2. slow release – cell damage and dearth occurs over long time period 3. Periodic release – viruses can remain in certain body cells (e. g. nerve cells) for life; they may be release from body cells periodically and enter new target cells. (herpes can remain in nerve cells; be released epriodically and enter new epithelial cells; damages the epithelial cells) 4. be integrated into host chromosome and stay there in dormant form until it is reactivated 33 Lytic Infection Persistent Infection Latent Infection Transformation to cancerous cell Rapid release of new viruses from infecded cell caused cell death.The symptoms of the disease depend on which cells are killed Slow release of new viruses causes cell to remain alive and continue to produce new viruses for a prolonged period of time. Delay between infection and symptoms. Virus is present in the cell without harming the cell. Symptoms beging when the virus begins actively replication and causes cell death when new viruses exit the cell. Certain viruses insert their genetic information into host cell chromosomes. Some carry oncogenes (cancer – causing genes) that are active in the host cell. Some disrupt the functioning of the host cell's genes that regulate cell division, causing the cell to become cancerous. Viruses and Disease 1.Can cause cell damage as they leave the host cell; the cell damage causes the symptoms 2. Can cause cancer when they insert themselves into host chromosome or by producing factors that affect the host genes that regulate cell division Genital Herpes Cause virus Herpes simplex -type 1 (HSV-1) – usually associated with fever blisters + cold sores -type 2 (HSV-2) – usually causes similar sores in genital area Symptoms (if there are symptoms) first may have a tingling or itching sensation (called the prodrome) 2-20 days after contact blisters of fluid filled sores 1st attack lasts about 3 wk s (1wk-4wks) can use ointments to relieve the pain will go away whether treated or not Also cause cancer hen they insert themselves into host chromosome o r by producing factors that affect the host genes that regulate cell division Viruses and Disease 34 Genital Warts in about half (50%) of people with herpes: blisters reform periodically usually at times of stress because the virus moves the the sacral ganglia of the spinal cord not affected by the human immune system here can be reawakened + cause new sores -maybe 2x month or 1x in 10yrs -NO CURE Genital Herpes spread by contact of infected and uinfected surface no sex while blister present or during prodrome or for at least 10 days after blisters are gone use a condom at all timeseven when no blisters are present erpes can be spread to newborn if deliver vaginally while virus is present if infant's infection is in liver and central nervous system-can be fatal Diagnosis Examination of sores Culture fluid from sores Blood test for antibodies in women-Pap test Treatment -Syptoms only Acyclovir (Zovirax):-reduce severity of first outbreak and reduce frequency of recurrences Human Papilloma Virus (HPV) usually transmitted by sexual contact 50-70% of those who have sex with an infected person will get them more likely if on the pill or pregnant or uncircumsized appear 1-2 months after contact, maybe longer appearance of growth on dry areas- brownish on moist areas-pink they grow may cause foul-smelling discharge may itch -warts can be removed by: 1. freezing 2. burning 3. laser 4. treated with a chemical (podophyllin) that is painted onleft 4 hrs. washed away warts fall off * virus may remain Diagnosis appearance of wart in women-Pap test can look for DNA of HPV inside cells 35 Genital Warts *ASSOCIATED WITH INCREASED RISK OF CERVICAL CANCER -HPV found in 90% of women with cervical cancer There is now a vaccine against HPV and, therefore, against cervical cancer *ASSOCIATED WITH AND INCREASED RISK OF CANCER OF P ENIS 36 BODY DEFENSES Innate Responses – Nonspecific Physical and Chemical Barriers Adaptive defense: Specific defenses (directed at specific target): The immune system: 1. Specific for particular â€Å"invader† (antigen) 2. Has memory for specific antigens previously encountered Lymphocyte encounters antigen Immune responses have 1.Specificity: Specific for particular â€Å"invader† (antigen) Antigen = a large molecule (not recognized as belonging in the body) that triggers an immune response Ex: antigen can be on the surface of a bacterium or virus etc. ; can be a bacterial toxin Your body cells have markers (molecules) that label them as belonging in your body Each lymphocyte has receptors on its surface that recognize a specific antigen When that antigen is present, it causes that lymphocyte to divide many times Effector cells Memory cells Effector cells attack specific target Memory cells remain and provide a quick response in subsequent exposure to same an tigen Third line of defense: Specific defenses (directed at specific target): The immune system: Immune system is 1. specific for a particular ? invader? antigen) 2. has memory for specific antigen previously encountered Creates an army of lymphocytes specialized to attack that antigen These are called Effector cells 2. Memory: have memory for specific antigen previously encountered Memory lymphocytes remain to cause a quick response the next time the same antigen is encountered 37 STEPS IN IMMUNE RESPONSE 1. Threat: foreign cell or molecule enters body 2. Detection Macrophage: detects invader engulfs invader digests invader 3. Alert: Macrophage places a piece of consumed antigen on its plasma membrane attached to a self marker presents the antigen to a helper T cell activates the helper T cell 4.Alarm: Helper T Cell: after activation by a macrophage, it divides, forming effector helper T cells and memory helper T cells turns â€Å"on† both lines of immune response to fight t hat specific antigen by activating B cells and T cells 5. Build specific defense (clonal selection) Lymphocyte encounters antigen Effector cells attack specific target Memory cells remain and provide a quick response in subsequent exposure to same antigen 6. Defense A. Antibody-mediated immune response Effector B cell = Plasma cell Plasma cells secrete antibodies Targets = antigens outside of cell or on surface of cell B. Cell-mediated immune response Effector T cell = cytotoxic T cell Cytotoxic T cells kill foreign cells by causing them to burst Targets = cells bearing antigens (any cells recognized as foreign: e. g. nfected cell, bacteria, cancer cell) 7. Continued surveillance memory cells remain 8. Withdrawal of forces After antigen has been destroyed suppressor T cells shut down the immune response Effector cells cells Memory 38 A. Antibody-mediated immune response Effector B cell = Plasma cell Plasma cells secrete antibodies Targets = antigens outside of cell or on surface of cell An antibody is a Y-shaped protein designed to recognize a specific antigen Antibodies help defend against a specific antigen Can only work against antigens that are free in blood Antibodies bind to the antigen Antibodies are secreted by plasma cells (effector B cells) Ways that Antibodies can Work 1.Neutralization – bind to antigen prevent virus from being able to enter host cell inactivate toxin 2. Agglutination and precipitation -clumps â€Å"invaders† together makes it easier for other cells to engulf them 3. Activation of complement system complement (system) is a group of proteins that pokes holes causes â€Å"invader† to burst B. Cell-mediated immune response Effector T cell = cytotoxic T cell Cytotoxic T cells kill foreign cells by causing them to burst Targets = cells bearing antigens (any cells recognized as foreign: e. g. infected cell, bacteria, cancer cell) Cytotoxic T cells secrete proteins called perforins that poke holes in â€Å"invaderâ₠¬  or foreign cells, causing them to burst 39Cells Involved In the Immune System Macrophage: an antigen presenting cells engulfs and digests antigens places a piece of consumed antigen on its plasma membrane presents the antigen to a helper T cell activates the helper T cell B Cells: T Cells: Helper T Cell: the â€Å"on† switch for both lines of immune response after activation by a macrophage, it divides, forming effector helper T cells and memory helper T cells activate B cells and T cells Cytotoxic T cell: (effector T cell) responsible for cellmediated immune responses when activated by helper T cell, it divides to form effector cytotoxic T cells and memory cytotoxic T cells destroys cellular targets, such as virusinfected body cells, bacteria, fungi, arasites, and cancer cells Suppressor T cell: the â€Å"off† switch for immune responses suppresses the activity of B cells and T cells after the foreign cell or molecule has been successfully destroyed involved in an tibodymediated responses when activated by helper T cells, it divides to form plasma cells and memory cells Plasma Cell: effector in antibodymediated response secretes antibodies specific to the invader Memory Cells: responsible for memory of immune system generated by B cells or any type of T cell during an immune response enable quick and efficient response on subsequent exposures of the antigen may live for years 40 AIDS Acquired Immune Deficiency Syndrome Caused by HIV Human Immunodeficiency Virus HIV infects T cells T cells become HIV factories Organism enters body Macrophage detects it HIV kills helper T cells so THIS doesn’t happen Activates a helper T cell Stimulates division of cytotoxic T cells (attack foreign cells) As helper T cell numbers drop, the body becomes increasingly susceptible to infection Stimulates B cells to form antibodies (destroys the infectious organism) 41